Prevalence and Antimicrobial Susceptibility of Wound Pathogens in a Tertiary Care Hospital in Kashmir: A Cross-sectional Study.

IF 2.8 Q2 INFECTIOUS DISEASES

Infection and Chemotherapy Pub Date : 2024-12-01 DOI:10.3947/ic.2024.0083

Tabeen Mansoor, Dekyong Angmo, Nahid Nehvi

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引用次数: 0

Abstract

Background: Wound infections significantly impact morbidity, mortality, and healthcare costs globally. The Kashmir Valley's unique geographical and climatic conditions, coupled with resource constraints and antibiotic misuse, complicate managing these infections effectively. This study aimed to identify predominant bacterial pathogens in wound infections at a tertiary care hospital in Kashmir, determine their antibiotic susceptibility profiles, and estimate the prevalence of multidrug-resistant (MDR) strains.

Materials and methods: A prospective cross-sectional study was conducted from January to June 2023 at the Government Medical College, Srinagar. Pus samples from wound infections were aseptically collected and processed following standard microbiological protocols. Antibiotic susceptibility testing utilized the Kirby-Bauer disk diffusion method, adhering to Clinical and Laboratory Standards Institute guidelines. Data were analyzed using IBM SPSS statistics.

Results: Out of 4,378 samples analyzed, bacterial growth was observed in 1,921 samples, representing 43.9% of the total. Among the bacterial isolates, Gram-negative bacilli accounted for 73.5%, with Escherichia coli being the most prevalent at 27.9%. Among Gram-positive cocci, Staphylococcus aureus predominated, comprising 25.9% of the isolates. Methicillin-resistant S. aureus exhibited 100% susceptibility to linezolid but low susceptibility to erythromycin (27.0%) and clindamycin (24.0%). E. coli demonstrated high susceptibility to tigecycline (97.4%) and amikacin (75.0%), but lower susceptibility to imipenem (45.0%) and piperacillin-tazobactam (57.8%).

Conclusion: The substantial wound infection burden and high MDR prevalence in Kashmir necessitate comprehensive antimicrobial stewardship and infection control programs. Regular surveillance, education, and research are crucial to address antibiotic resistance and ensure effective wound infection management in the region.

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克什米尔一家三级护理医院伤口病原菌的患病率和抗菌药物敏感性：一项横断面研究。

背景：伤口感染显著影响全球发病率、死亡率和医疗保健成本。克什米尔山谷独特的地理和气候条件，加上资源限制和抗生素滥用，使有效管理这些感染复杂化。本研究旨在确定克什米尔一家三级护理医院伤口感染的主要细菌病原体，确定其抗生素敏感性概况，并估计多重耐药（MDR）菌株的患病率。材料和方法：一项前瞻性横断面研究于2023年1月至6月在斯利那加政府医学院进行。无菌收集伤口感染脓液样本，并按照标准微生物学方案进行处理。抗生素敏感性测试采用Kirby-Bauer圆盘扩散法，遵循临床和实验室标准协会的指导方针。数据采用IBM SPSS统计软件进行分析。结果：在分析的4378个样本中，1921个样本中观察到细菌生长，占总数的43.9%。其中革兰氏阴性杆菌占73.5%，大肠杆菌最多，占27.9%。在革兰氏阳性球菌中，金黄色葡萄球菌占多数，占25.9%。耐甲氧西林金黄色葡萄球菌对利奈唑胺的敏感性为100%，对红霉素（27.0%）和克林霉素（24.0%）的敏感性低。大肠杆菌对替加环素（97.4%）和阿米卡星（75.0%）的敏感性较高，对亚胺培南（45.0%）和哌拉西林-他唑巴坦（57.8%）的敏感性较低。结论：克什米尔地区伤口感染负担沉重，耐多药耐药患病率高，需要全面的抗菌药物管理和感染控制规划。定期监测、教育和研究对于解决该地区的抗生素耐药性和确保有效的伤口感染管理至关重要。

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