Development and Prevention of Biofilm on Cochlear Implants: A Systematic Review.

IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Alexios Tsikopoulos, Konstantinos Tsikopoulos, Konstantinos Sidiropoulos, Gabriele Meroni, Stefanos Triaridis, Lorenzo Drago, Paraskevi Papaioannidou
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Abstract

Background and Objectives: Biofilm formation on cochlear implants (CIs) poses a major problem for surgeons, leading to a high incidence of explantation and revision surgery. Therefore, developing appropriate and cost-effective biofilm detection and prevention techniques is of the essence. In this systematic review, we sought to investigate the development of biofilm formation on CIs. We also elaborated on experimental preventative biofilm measures. Materials and Methods: We conducted a systematic search of both in vitro and in vivo literature published in PubMed, Scopus, and ScienceDirect, until 15 June 2024, for published studies evaluating the biofilm formation and strategies for inhibiting biofilm formation on CIs. Depending on the type of the included study, we assessed quality with the modified Consolidated Standards of Reporting Trials tool, the Joanna Briggs Institute Case Reports Critical Appraisal Tool, a modified Delphi technique, and the ROBINS-I tool. We synthesized the available information on biofilm formation on CIs and the infection prevention capacity of the included antibiofilm agents. Results: A total of 26 studies were included in this systematic review. Biofilms in CIs are usually localized in their recesses such as their removable magnet pocket as opposed to their smooth surfaces. S. aureus and P. aeruginosa are the most commonly isolated microorganisms, and they tend to be strong biofilm producers. The optimal treatment strategy for a biofilm-infected CI is explantation. Most of the examined biofilm prevention methods in CIs present sufficient antibiofilm activity. Conclusions: Biofilm formation in CIs is considered one of the most dreadful complications. There have been no specific guidelines for the treatment of those cases, with removal and/or replacement of the CI being the treatment of choice. Various experimental prevention methods provide promising antibiofilm activity both in vivo and in vitro.

人工耳蜗生物膜的形成与防治:系统综述。
背景与目的:人工耳蜗生物膜的形成是外科医生面临的一个主要问题,导致人工耳蜗植入术和翻修手术的发生率很高。因此,开发合适且具有成本效益的生物膜检测和预防技术至关重要。在这篇系统综述中,我们试图研究生物膜形成在CIs上的发展。并阐述了实验性的生物膜预防措施。材料和方法:我们对PubMed、Scopus和ScienceDirect上发表的体外和体内文献进行了系统检索,直到2024年6月15日,以评估CIs上生物膜形成和抑制生物膜形成策略的已发表研究。根据纳入研究的类型,我们使用改进的综合报告试验标准工具、乔安娜布里格斯研究所病例报告关键评估工具、改进的德尔菲技术和ROBINS-I工具来评估质量。我们综合了现有的关于CIs生物膜形成的信息和所含抗生素膜剂的感染预防能力。结果:本系统综述共纳入26项研究。生物膜通常定位于其凹槽,如可移动的磁铁袋,而不是其光滑的表面。金黄色葡萄球菌和铜绿假单胞菌是最常见的分离微生物,它们往往是强生物膜生产者。生物膜感染CI的最佳治疗策略是外植。大多数检测到的CIs生物膜预防方法都具有足够的抗生物膜活性。结论:生物膜形成被认为是CIs最可怕的并发症之一。对于这些病例的治疗还没有具体的指导方针,切除和/或更换CI是治疗的选择。各种实验预防方法在体内和体外都提供了有希望的抗生素膜活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medicina-Lithuania
Medicina-Lithuania 医学-医学:内科
CiteScore
3.30
自引率
3.80%
发文量
1578
审稿时长
25.04 days
期刊介绍: The journal’s main focus is on reviews as well as clinical and experimental investigations. The journal aims to advance knowledge related to problems in medicine in developing countries as well as developed economies, to disseminate research on global health, and to promote and foster prevention and treatment of diseases worldwide. MEDICINA publications cater to clinicians, diagnosticians and researchers, and serve as a forum to discuss the current status of health-related matters and their impact on a global and local scale.
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