Association Between Chlamydia trachomatis and Helicobacter pylori with Inflammation in Polycystic Ovary Syndrome: A Cross-Sectional Study.

IF 2.4 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Yeşim Alpay Çağlar, Mine Islimye Taşkin
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引用次数: 0

Abstract

Objective: Chronic low-grade inflammation occurs in polycystic ovary syndrome (PCOS), and there are many contributing factors. In this study, we aimed to investigate Helicobacter pylori and Chlamydia trachomatis infections in patients with PCOS and to evaluate the association between these microorganisms and the inflammatory process in the etiology of the disease. Materials and Methods: This comparative cross-sectional clinical study was conducted at Balıkesir University Hospital and included 40 female patients diagnosed with PCOS in the gynecology outpatients clinic and 40 healthy female controls. Demographic data were recorded. Blood hormone profiles and biochemical parameters were analyzed. An enzyme-linked immunosorbent assay test kit was used to measure H. pylori IgG and C. trachomatis IgG. Results: According to the analysis of the study data, there was no significant association between the PCOS and non-PCOS groups with regard to the presence of Helicobacter pylori IgG (p = 0.1) and Chlamydia trachomatis IgG (p = 0.338). CRP levels were significantly higher in the PCOS group (p = 0.001). In the subgroup analyses, the CRP levels were not significantly different between the H. pylori and C. trachomatis antibody-positive and -negative groups. Diabetes mellitus was significantly associated with PCOS (p = 0.005). The smoking rate was significantly higher in the control group than in the PCOS group (p = 0.036). Compared to the control group, the BMI, LH, HOMA-IR, TSH, and TG levels were significantly higher in participants with PCOS (p = 0.000; p = 0.004; p = 0.001; p = 0.001; p = 0.043; p = 0.000). FSH was lower in PCOS patients compared to controls (p = 001). In the subgroup analyses, no significant differences were found between the H. pylori and C. trachomatis antibody-positive and -negative groups. Conclusions: PCOS is characterized by chronic nonspecific low-grade inflammation. The etiopathogenesis of PCOS involves comorbidities that cause a chronic inflammatory process. However, the possible infective causes still seem to be open to investigation. In particular, studies on microbiota and periodontal diseases in PCOS may provide important contributions.

沙眼衣原体和幽门螺杆菌与多囊卵巢综合征炎症的相关性:一项横断面研究。
目的:多囊卵巢综合征(PCOS)发生慢性低度炎症,其影响因素较多。在这项研究中,我们旨在研究幽门螺杆菌和沙眼衣原体感染在多囊卵巢综合征患者中的作用,并评估这些微生物与炎症过程在多囊卵巢综合征病因学中的关系。材料与方法:本比较横断面临床研究在Balıkesir大学医院进行,选取40例妇科门诊诊断为PCOS的女性患者和40例健康女性作为对照。记录人口统计数据。分析血液激素谱和生化指标。采用酶联免疫吸附法检测幽门螺杆菌IgG和沙眼衣原体IgG。结果:根据研究资料分析,PCOS组与非PCOS组幽门螺杆菌IgG (p = 0.1)和沙眼衣原体IgG (p = 0.338)的存在无显著相关性。PCOS组CRP水平明显升高(p = 0.001)。在亚组分析中,CRP水平在幽门螺杆菌和沙眼衣原体抗体阳性和阴性组之间没有显著差异。糖尿病与PCOS有显著相关性(p = 0.005)。对照组的吸烟率明显高于PCOS组(p = 0.036)。与对照组相比,多囊卵巢综合征患者的BMI、LH、HOMA-IR、TSH和TG水平显著高于对照组(p = 0.000;P = 0.004;P = 0.001;P = 0.001;P = 0.043;P = 0.000)。与对照组相比,PCOS患者FSH较低(p = 001)。在亚组分析中,幽门螺杆菌和沙眼衣原体抗体阳性和阴性组之间没有发现显著差异。结论:PCOS以慢性非特异性低度炎症为特征。多囊卵巢综合征的发病机制涉及引起慢性炎症过程的合并症。然而,可能的感染原因似乎仍有待调查。特别是对多囊卵巢综合征的微生物群和牙周病的研究可能会提供重要的贡献。
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来源期刊
Medicina-Lithuania
Medicina-Lithuania 医学-医学:内科
CiteScore
3.30
自引率
3.80%
发文量
1578
审稿时长
25.04 days
期刊介绍: The journal’s main focus is on reviews as well as clinical and experimental investigations. The journal aims to advance knowledge related to problems in medicine in developing countries as well as developed economies, to disseminate research on global health, and to promote and foster prevention and treatment of diseases worldwide. MEDICINA publications cater to clinicians, diagnosticians and researchers, and serve as a forum to discuss the current status of health-related matters and their impact on a global and local scale.
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