Street Pharmacology: Toxico-Dermatology of Injection Drug Use.

IF 2.9 4区医学

Journal of Clinical Pharmacology Pub Date : 2025-01-09 DOI:10.1002/jcph.6176

David F Lehmann, Aryana Nazem, Jeanna Marraffa, Ramsay Sami Farah

引用次数: 0

Abstract

Street medicine is a point-of-care, mobile approach that services the needs of unhoused individuals who are otherwise unable to access medical care in traditional settings. The prevalence of injection drug use combines with the pipeline of illicit substances, to produce a constellation of severe, potentially life-threatening dermatological disorders unique to this population. This review applies principles of clinical pharmacology to clarify the mechanisms underlying the dermatological toxicity of xylazine, desomorphine, and 3,4-methylenedioxymethamphetamine (MDMA).

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街头药理学：注射用药的毒理学-皮肤病学。

街头医疗是一种即时护理的流动方法，可满足在传统环境中无法获得医疗服务的无家可归者的需求。注射吸毒的流行与非法药物的流通相结合，产生了这一人群特有的一系列严重的、可能危及生命的皮肤病。本文运用临床药理学原理阐明了噻嗪、去吗啡和3,4-亚甲基二氧基甲基苯丙胺（MDMA）皮肤毒性的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Pharmacology PHARMACOLOGY & PHARMACY-

自引率

3.40%

发文量

期刊介绍： The Journal of Clinical Pharmacology (JCP) is a Human Pharmacology journal designed to provide physicians, pharmacists, research scientists, regulatory scientists, drug developers and academic colleagues a forum to present research in all aspects of Clinical Pharmacology. This includes original research in pharmacokinetics, pharmacogenetics/pharmacogenomics, pharmacometrics, physiologic based pharmacokinetic modeling, drug interactions, therapeutic drug monitoring, regulatory sciences (including unique methods of data analysis), special population studies, drug development, pharmacovigilance, womens’ health, pediatric pharmacology, and pharmacodynamics. Additionally, JCP publishes review articles, commentaries and educational manuscripts. The Journal also serves as an instrument to disseminate Public Policy statements from the American College of Clinical Pharmacology.