The Journal of Clinical Pharmacology

First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Oral Complement Factor D Inhibitor BCX9930 in Healthy Participants

Pub Date : 2025-04-28 DOI: 10.1002/jcph.70032 Matthew Davidson PharmD, Xilin Chen PhD, Amanda Mathis PhD, Sylvia Dobo MD, Melanie Cornpropst PharmD, PhD, Fugang Zhu PhD, Cynthia Parker BS, David Reynolds PhD, Yarlagadda S. Babu PhD, Stuart Mair MBChB, DRCOG, DCPSA, FFPM, William P. Sheridan MB, BS

Expansion of a Pharmacokinetic Model for Diazepam to Characterize Real-World IV and Oral Data in Children With and Without Obesity

Pub Date : 2025-04-28 DOI: 10.1002/jcph.70027 Sean M. McCann BS, Jiali Wen PharmD, Stephen J. Balevic MD, PhD, William J. Muller MD, PhD, Amira Al-Uzri MD, Chi D. Hornik PharmD, Marisa L. Meyer DO, Sarah G. Anderson MS, Elizabeth H. Payne PhD, Sitora Turdalieva MS, James M. Chamberlain MD, Daniel Gonzalez PharmD, PhD, the Best Pharmaceuticals for Children Act Pediatric Trials Network Steering Committee

Crowdsourcing Proposal Supporting Patient Engagement in Parkinson's Disease: A Digital Research Environment (DRE)-Enabled, Patient Swarm Approach to Develop QSP Models

Pub Date : 2025-04-22 DOI: 10.1002/jcph.70028 Jeffrey S. Barrett PhD, Benedetto Piccoli PhD, Christopher Denaro PhD, Stephan Schmidt PhD, Valvanera Vozmediano PhD, Serge Guzy PhD, Kyle Barrett BS, Kevin Kwok MS, Scott Russell MS, David Sibbald MS