Causal associations between dietary factors with head and neck cancer: A two-sample Mendelian randomization study

IF 1.6 4区医学 Q2 OTORHINOLARYNGOLOGY

Laryngoscope Investigative Otolaryngology Pub Date : 2025-01-07 DOI:10.1002/lio2.70070

Yali Xu MM, Guangui Chen MD, PhD, Min Mao MM, Minqiong Jiang BS, Jinhai Chen MM, Zhaoen Ma MD

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引用次数: 0

Abstract

Objective

Although an association exists between dietary habits and head and neck cancer (HNC), the direct cause-and-effect connection remains elusive. Our objective was to investigate the causal associations between dietary factors and the likelihood of developing HNC.

Methods

Genome-wide association study (GWAS) summary statistics for dietary habits were screened from the UK Biobank, the OncoArray Oral Cavity and Oropharyngeal Cancer consortium, and the FinnGen biobank for HNC. A two-sample Mendelian randomization (MR) analysis was utilized to establish causality. The primary method of analysis was inverse variance weighting (IVW).

Results

Clear evidence of an inverse association existed between dried fruit intake and HNC in both cohorts (OncoArray consortium: IVW OR = 0.183; 95% CI, 0.037–0.915; p = .03864; FinnGen: IVW OR = 0.281; 95% CI, 0.115–0.688; p = .00547). In addition, fresh fruit (IVW-mre OR = 0.066; 95% CI, 0.011–0.413; p = .00369), beef (IVW OR = 15.094; 95% CI, 1.950–116.853; p = .00934), and lamb/mutton intakes (IVW OR = 5.799; 95% CI, 1.044–32.200; p = .0448) were significantly associated with HNC in the OncoArray consortium cohort.

Conclusions

Dried fruit intake may be a protective factor against HNC. The association of fresh fruit and red meat intakes with HNC warrants careful interpretation. Additional studies are necessary to explore potential mechanisms for further evidence.

Level of evidence: III

Abstract Image

查看原文本刊更多论文

饮食因素与头颈癌之间的因果关系：一项双样本孟德尔随机研究。

目的：虽然饮食习惯与头颈癌（HNC）之间存在关联，但直接的因果关系仍然难以捉摸。我们的目的是调查饮食因素与发生HNC的可能性之间的因果关系。方法：从英国生物银行（UK Biobank）、OncoArray口腔和口咽癌联盟（OncoArray Oral and or咽癌consortium）和FinnGen生物银行中筛选饮食习惯的全基因组关联研究（GWAS）汇总统计数据。采用双样本孟德尔随机化（MR）分析来确定因果关系。主要分析方法为方差逆加权（IVW）。结果：明确的证据表明，在两个队列中，干果摄入量与HNC之间存在负相关(OncoArray联盟：IVW OR = 0.183；95% ci, 0.037-0.915；p = .03864；FinnGen: IVW OR = 0.281；95% ci, 0.115-0.688；p = .00547)。此外，新鲜水果(IVW-mre OR = 0.066；95% ci, 0.011-0.413；p = 0.00369)，牛肉(IVW OR = 15.094；95% ci, 1.950-116.853；p = 0.00934)，羔羊/羊肉摄入量(IVW OR = 5.799；95% ci, 1.044-32.200；p = 0.0448)在OncoArray联盟队列中与HNC显著相关。结论：干果摄入可能是预防HNC的保护因素。新鲜水果和红肉摄入与HNC之间的关系值得仔细解释。需要进一步的研究来探索潜在的机制以获得进一步的证据。证据水平：III。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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