Could New Palm-Free Structured Lipids Mitigate Postprandial Hyperlipidemia and Inflammation Induced by High-Fat Meals in Swiss Mice?

IF 6.8 4区医学 Q1 NUTRITION & DIETETICS

Journal of the American Nutrition Association Pub Date : 2025-01-09 DOI:10.1080/27697061.2024.2449524

Alice da Silva Malveira, Vanessa Alves, Gabriela de Matuoka E Chiocchetti, Alessandra Gambero, Amanda Rejane Alves de Ávila, Guilherme de Figueiredo Furtado, Juliana Alves Macedo, Valdecir Luccas, Gabriela Alves Macedo

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引用次数: 0

Abstract

A high-fat meal can cause postprandial hyperlipemia, initiating an acute inflammatory response. New structured lipids (SLs) free from trans and palm fatty acids are emerging as food structurants.

Objective: We evaluated the postprandial response and inflammatory profiles in Swiss mice after oral administration of SLs in high-fat meals.

Methods: SLs with different contents of long-chain saturated fatty acids were synthesized through an interesterification process involving soybean, peanut oils and crambe hard fat.

Results: SLs containing 23.79% (SL1), 32.01% (SL2), and 43.87% (SL3) of total saturated fatty acids reduced the absorption of serum triglycerides and appeared to mitigate postprandial inflammation by interleukin-6. A faster gastric emptying rate after consuming SL3 was corroborated by the fecal presence of behenic acid.

Conclusions: Our results suggest that SLs, free from palm and trans fats, may have the potential to mitigate inflammation, reduce the postprandial response, and lower absorption upon acute consumption.

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新的无棕榈结构脂能减轻瑞士小鼠高脂餐诱导的餐后高脂血症和炎症吗？

高脂肪饮食会导致餐后高脂血症，引发急性炎症反应。不含反式脂肪酸和棕榈脂肪酸的新型结构脂（SLs）正在成为食品结构剂。目的：我们评估瑞士小鼠在高脂肪膳食中口服SLs后的餐后反应和炎症特征。方法：以大豆油、花生油和豆粕硬脂肪为原料，采用酯化法合成不同含量的长链饱和脂肪酸的短链氨基酸。结果：含有23.79% （SL1）、32.01% （SL2）和43.87% （SL3）总饱和脂肪酸的单糖可减少血清甘油三酯的吸收，并可通过白细胞介素-6减轻餐后炎症。食用SL3后，胃排空速度更快，粪便中存在behen酸证实了这一点。结论：我们的研究结果表明，不含棕榈脂肪和反式脂肪的SLs可能具有减轻炎症、减少餐后反应和降低急性食用时吸收的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Nutrition Association

CiteScore

2.50

自引率

0.00%

发文量