Lymph Node Metastasis for pN+ Superficial Esophageal Squamous Cell Carcinoma.

IF 2.3 3区医学 Q3 ONCOLOGY

Thoracic Cancer Pub Date : 2025-01-01 DOI:10.1111/1759-7714.15504

Yafan Yang, Liyan Xue, Xiankai Chen, Mingqiang Kang, Renquan Zhang, Hui Tian, Jianqun Ma, Maoyong Fu, Jinchang Wei, Qi Liu, Anlin Hao, Yi He, Ruixiang Zhang, Hounai Xie, Lei Xu, Peng Luo, Jianjun Qin, Yin Li

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引用次数: 0

Abstract

Objectives: This study aimed to analyze lymph node metastasis (LNM) distribution in superficial esophageal squamous cell carcinoma (ESCC) and its impact factors on survival.

Methods: We reviewed 241 pT1N+ ESCC cases between February 2012 and April 2022 from 10 Chinese hospitals with a high volume of esophageal cancer (EC). We analyzed clinicopathological data to identify overall survival (OS) risk factors and LNM distribution in relation to tumor invasion depth.

Results: Of the 241 patients, 26 (10.8%) had pT1a cancer and 215 (89.2%) had pT1b cancer. We showed that N3 stage, ≤ 28 lymphadenectomies, and nerve infiltration (NI) were negative factors for OS in superficial pN+ ESCC, whereas the OS was not definitively affected by the tumor depth and the choice of adjuvant therapy. In general, the LNM rates of the 193 pT1N+ ESCC cases can be ranked in the following order: station 106recR > station 106recL > station 1 > station 7 > station 2. With deeper tumor invasion, the higher LNM rate was observed near the bilateral recurrent laryngeal nerves (RLN), but there was no statistically significant difference.

Conclusions: In superficial ESCC, LNM was frequently observed along the 106recR (35.8%) and 106recL (25.6%) stations. Advanced N-staging (N3) was a major negative impact factor in prognosis, and adequate lymph nodes dissected (LND) (N > 28) improved OS of pT1N+ ESCC. However, in superficial ESCC, tumor infiltration depth did not affect patients' OS or the distribution of positive LNs. The optimal adjuvant treatment that favors survival for these patients required further investigation.

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pN+浅表食管鳞状细胞癌的淋巴结转移。

目的：分析浅表食管鳞状细胞癌（ESCC）的淋巴结转移（LNM）分布及其对生存的影响因素。方法：回顾性分析2012年2月至2022年4月中国10家食管癌（EC）高容量医院的241例pT1N+ ESCC病例。我们分析了临床病理数据，以确定总生存（OS）危险因素和与肿瘤侵袭深度相关的LNM分布。结果：241例患者中，pT1a癌26例（10.8%），pT1b癌215例（89.2%）。我们发现，N3期、≤28淋巴结切除术和神经浸润（NI）是浅表pN+ ESCC的OS的负性因素，而OS与肿瘤深度和辅助治疗的选择没有明确的影响。总的来说，193例pT1N+ ESCC病例的LNM率排序为：106recR站>站106recL站>站1>站7>站2。肿瘤浸润越深，双侧喉返神经（RLN）附近的LNM发生率越高，但差异无统计学意义。结论：浅表ESCC中，106recR（35.8%）和106recL（25.6%）常发生LNM。晚期N分期（N3）是影响预后的主要负面因素，充分淋巴结清扫（LND）（N bbb28）改善了pT1N+ ESCC的OS。然而，在浅表ESCC中，肿瘤浸润深度不影响患者的OS或阳性LNs的分布。有利于这些患者生存的最佳辅助治疗需要进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thoracic Cancer ONCOLOGY-RESPIRATORY SYSTEM

CiteScore

5.20

自引率

3.40%

发文量

439

审稿时长

2 months

期刊介绍： Thoracic Cancer aims to facilitate international collaboration and exchange of comprehensive and cutting-edge information on basic, translational, and applied clinical research in lung cancer, esophageal cancer, mediastinal cancer, breast cancer and other thoracic malignancies. Prevention, treatment and research relevant to Asia-Pacific is a focus area, but submissions from all regions are welcomed. The editors encourage contributions relevant to prevention, general thoracic surgery, medical oncology, radiology, radiation medicine, pathology, basic cancer research, as well as epidemiological and translational studies in thoracic cancer. Thoracic Cancer is the official publication of the Chinese Society of Lung Cancer, International Chinese Society of Thoracic Surgery and is endorsed by the Korean Association for the Study of Lung Cancer and the Hong Kong Cancer Therapy Society. The Journal publishes a range of article types including: Editorials, Invited Reviews, Mini Reviews, Original Articles, Clinical Guidelines, Technological Notes, Imaging in thoracic cancer, Meeting Reports, Case Reports, Letters to the Editor, Commentaries, and Brief Reports.