Effect of pre-conception serum vitamin D level on pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer: a retrospective analysis.

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Reproductive Biology and Endocrinology Pub Date : 2025-01-09 DOI:10.1186/s12958-025-01343-w

Aaron H Y Chan, Jennifer K Y Ko, Raymond H W Li, Tat On Chan, Ernest H Y Ng

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Abstract

Background: This study aims to investigate the association of pre-conception vitamin D levels on adverse pregnancy outcomes in women undergoing in vitro fertilization with fresh embryo transfer.

Methods: This was a retrospective cohort study using archived serum 25-hydroxyvitamin D measured in the pre-conception period before ovarian stimulation in patients undergoing in vitro fertilization with fresh autologous embryo transfer. A total of 306 women were included and adverse pregnancy outcomes in their resulting pregnancy were recorded. Patients who were vitamin D deficient (< 20ng/ml) were compared with those who were non-deficient (≥20ng/ml) and analysed for any association with adverse pregnancy outcomes.

Results: A total of 16/306 (5.3%) patients had hypertensive disorders of pregnancy (gestational hypertension and/or pre-eclampsia). The adjusted odds ratio for hypertensive disorders of pregnancy using vitamin D deficiency as a reference was 0.190 (95% CI 0.042-0.852) (p = 0.030). Other pregnancy complications were not significantly different with regards to pre-conception vitamin D status.

Conclusions: Pre-conception vitamin D deficiency is associated with an increased risk of hypertensive disorders in pregnancy in women undergoing in vitro fertilization with fresh embryo transfer.

Trial registration: HKUCTR 2361 (9th March 2018).

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孕前血清维生素D水平对新鲜胚胎移植体外受精妇女妊娠结局的影响：回顾性分析

背景：本研究旨在探讨孕前维生素D水平与新鲜胚胎移植体外受精妇女不良妊娠结局的关系。方法：采用回顾性队列研究方法，对新鲜自体胚胎移植体外受精患者在卵巢刺激前的妊娠前期血清25-羟基维生素D进行测定。总共有306名妇女被纳入研究，并记录了她们怀孕后的不良妊娠结果。结果：共有16/306（5.3%）患者存在妊娠期高血压疾病（妊娠期高血压和/或先兆子痫）。以维生素D缺乏为参照，妊娠期高血压疾病的校正优势比为0.190 (95% CI 0.042-0.852) （p = 0.030）。其他妊娠并发症与孕前维生素D水平没有显著差异。结论：孕前维生素D缺乏与新鲜胚胎移植体外受精妇女妊娠期高血压疾病风险增加有关。试验注册：HKUCTR 2361（2018年3月9日）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.