Epigenetic Modifications as Novel Therapeutic Strategies of Cancer Chemoprevention by Phytochemicals.

IF 3.5 3区医学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Pharmaceutical Research Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI:10.1007/s11095-024-03810-2

Hui-Hsia Hsieh, Min-Zhan Kuo, I-An Chen, Chien-Ju Lin, Victor Hsu, Wei-Chun HuangFu, Tien-Yuan Wu

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引用次数: 0

Abstract

Purpose: Epigenetic modifications, such as aberrant DNA methylation, histone alterations, non-coding RNA remodeling, and modulation of transcription factors, are pivotal in the pathogenesis of diverse malignancies. Reactive oxygen species (ROS) have the capacity to impact these epigenetic mechanisms, including DNA methylation, throughout the different stages of cancer development. Therefore, the aim of this review is to address the impact of.

Methods: Published papers were searched in Pubmed and Google Scholar databases using the keywords "epigenetic", or "DNA methylation", or "phytochemicals", or "chemoprevention" to prepare this review.

Results: There is mounting evidence indicating that diminishing ROS accumulation within cells can regulate the function of DNA methyltransferases (DNMTs). Moreover, activation of the cellular defense system can impede and potentially reverse the progression of tumors in cancerous cells. As a result, ROS scavengers, antioxidants, and demethylating agents have emerged as potential therapeutic approaches for specific types of cancer. Additionally, dietary phytochemicals present in fruits, vegetables, and herbs, which have been utilized for centuries, exhibit the capability to modulate transcription factors, decrease inflammation, deliver antioxidant benefits, induce cell-cycle arrest, and stimulate apoptosis.

Conclusion: These phytochemicals can also renew and reprogram the expression of genes that suppress cancer. Thus, prolonged exposure to phytochemicals at low doses represents an innovative therapeutic tactic for the prevention of cancer.

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表观遗传修饰作为植物化学物质预防癌症的新治疗策略。

目的：表观遗传修饰，如异常DNA甲基化、组蛋白改变、非编码RNA重塑和转录因子的调节，在多种恶性肿瘤的发病机制中起着关键作用。在癌症发展的不同阶段，活性氧（ROS）有能力影响这些表观遗传机制，包括DNA甲基化。因此，本次审查的目的是解决的影响。方法：以“表观遗传”、“DNA甲基化”、“植物化学”、“化学预防”等关键词在Pubmed和谷歌Scholar数据库中检索已发表的论文，准备本综述。结果：越来越多的证据表明，细胞内ROS积累的减少可以调节DNA甲基转移酶（dnmt）的功能。此外，激活细胞防御系统可以阻止并潜在地逆转癌细胞中肿瘤的进展。因此，活性氧清除剂、抗氧化剂和去甲基化剂已成为特定类型癌症的潜在治疗方法。此外，存在于水果、蔬菜和草药中的膳食植物化学物质，已经被使用了几个世纪，表现出调节转录因子、减少炎症、提供抗氧化益处、诱导细胞周期停滞和刺激细胞凋亡的能力。结论：这些植物化学物质还可以更新和重编程抑制癌症的基因表达。因此，长时间低剂量暴露于植物化学物质是预防癌症的一种创新治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutical Research 医学-化学综合

CiteScore

6.60

自引率

5.40%

发文量

276

审稿时长

3.4 months

期刊介绍： Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists, is committed to publishing novel research that is mechanism-based, hypothesis-driven and addresses significant issues in drug discovery, development and regulation. Current areas of interest include, but are not limited to: -(pre)formulation engineering and processing- computational biopharmaceutics- drug delivery and targeting- molecular biopharmaceutics and drug disposition (including cellular and molecular pharmacology)- pharmacokinetics, pharmacodynamics and pharmacogenetics. Research may involve nonclinical and clinical studies, and utilize both in vitro and in vivo approaches. Studies on small drug molecules, pharmaceutical solid materials (including biomaterials, polymers and nanoparticles) biotechnology products (including genes, peptides, proteins and vaccines), and genetically engineered cells are welcome.