Inflammatory Biomarkers and Tinnitus in Older Adults.

IF 1.3 4区医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY

Noise & Health Pub Date : 2024-10-01 Epub Date: 2024-12-30 DOI:10.4103/nah.nah_39_23

Licia Sayuri Tanaka, Luciana Lozza de Moraes Marchiori, Daiane de Almeida Soares Ciquinato, Denilson de Castro Teixeira, Glória de Moraes Marchiori, Braulio Henrique Magnani Branco, Regina Célia Poli-Frederico

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引用次数: 0

Abstract

Background: Tinnitus refers to a common disorder affecting older adults frequently. This condition can disturb mental health and psychological well-being and contribute to cognitive decline. Despite recent advances in research, its pathophysiology remains incompletely understood. Therefore, this study aimed to investigate the sensation of tinnitus, its consequences on the quality of life of older adults, and its correlation with cytokine levels.

Methods and material: This cross-sectional study included a sample of 103 independent older adults. Information regarding clinical history, tinnitus, and hearing loss was obtained through interviews. Assessment of tinnitus intensity and resulting impairments was conducted using Visual Analogue Scale (VAS) and Tinnitus Handicap Index (THI), respectively. Subjects underwent audiological evaluation and were measured for inflammatory markers. Statistical analyses included chi-square, Mann-Whitney, and Kruskal-Wallis tests and calculation of the effect size (Φ).

Results: The condition of older adults with tinnitus (51.5%) was associated with hearing loss and previous noise exposure. No differences were observed in the cytokines between groups with and without tinnitus (P > 0.05), whereas a difference was found in the interleukin-10 (IL-10) of the male group (P = 0.016; r = 0.69). In those with tinnitus, VAS had a median and (interquartile range) of 5 (2-7), and the values were 21 (10-38) for THI. In addition, VAS and minimum masking level exhibited a significant correlation with IL-6 (P = 0.018; rs = 0.335) and IL-2 (P = 0.035; rs = 0.299), respectively. Furthermore, the groups with intense and mild VAS presented different levels of tumour necrosis factor alpha (TNF-α) (P = 0.041; E2R = 0.12).

Conclusion: The results reveal an association between tinnitus and hearing loss and previous noise exposure. Moreover, increased sound-masking levels and VAS correlated with IL-2 and IL-6, respectively. TNF-α levels varied between the mild and intense VAS groups.

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炎症生物标志物与老年人耳鸣。

背景：耳鸣是一种经常影响老年人的常见疾病。这种情况会扰乱精神健康和心理健康，导致认知能力下降。尽管最近的研究取得了进展，但其病理生理学仍然不完全清楚。因此，本研究旨在探讨耳鸣的感觉、耳鸣对老年人生活质量的影响及其与细胞因子水平的相关性。方法和材料：这项横断面研究包括103名独立老年人的样本。通过访谈获得有关临床病史、耳鸣和听力损失的信息。分别采用视觉模拟量表（VAS）和耳鸣障碍指数（THI）评估耳鸣强度和耳鸣损伤。受试者接受听力学评估并测量炎症标志物。统计分析包括卡方检验、Mann-Whitney检验和Kruskal-Wallis检验和效应大小的计算（Φ）。结果：老年人耳鸣（51.5%）与听力损失和既往噪声暴露有关。耳鸣组与非耳鸣组细胞因子差异无统计学意义（P < 0.05），而男性组白细胞介素-10 （IL-10）差异有统计学意义(P = 0.016；r = 0.69)。在耳鸣患者中，VAS的中位数和四分位数范围为5 (2-7)，THI的值为21（10-38）。此外，VAS和最低掩蔽水平与IL-6呈显著相关(P = 0.018；rs = 0.335)和IL-2 (P = 0.035；Rs = 0.299)。重度和轻度VAS组患者肿瘤坏死因子α (TNF-α)水平差异有统计学意义(P = 0.041；e2r = 0.12)。结论：结果表明耳鸣和听力损失与先前的噪声暴露有关。此外，声掩蔽水平升高和VAS分别与IL-2和IL-6相关。TNF-α水平在轻度和重度VAS组之间存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Noise & Health AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

2.10

自引率

14.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Noise and Health is the only International Journal devoted to research on all aspects of noise and its effects on human health. An inter-disciplinary journal for all professions concerned with auditory and non-auditory effects of occupational, environmental, and leisure noise. It aims to provide a forum for presentation of novel research material on a broad range of topics associated with noise pollution, its control and its detrimental effects on hearing and health. It will cover issues from basic experimental science through clinical evaluation and management, technical aspects of noise reduction systems and solutions to environmental issues relating to social and public health policy.