Comparative effects of dexpanthenol and thymoquinone on colistin-induced neurotoxicity in rats.

IF 3.1 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Bulent Durdu, Yasemin Durdu, Eray Metin Guler, Abdurrahim Kocyigit, Gulay Okay
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Abstract

Colistin is used as a last-line treatment for multidrug-resistant gram-negative bacilli. Neurotoxicity limits clinic use of colistin. The use of colistin causes oxidative stress and inflammation. The antioxidant activities of dexpanthenol and thymoquinone are well known. The aim of this research was to investigate and compare the efficacy of dexpanthenol and thymoquinone in alleviating neurotoxicity in rats exposed to colistin therapy. The present study investigated inflammation biomarkers using enzyme-linked immunosorbent assay kits, whereas oxidative stress biomarkers were assessed using several photometric techniques. Serum and brain tissue samples were collected from rats with colistin neurotoxicity following treatment with dexpanthenol and thymoquinone. The administration of dexpanthenol markedly ameliorated colistin-induced oxidative stress indicators (except serum disulfide levels) and inflammatory biomarkers in rats. The effectiveness of thymoquinone exhibited a somewhat restricted scope. Thymoquinone demonstrated a notable enhancement in oxidative stress and inflammatory indicators in rats treated with colistin, except for serum disulfide levels, total antioxidant status (TAS), and brain tissue interleukin 6 (IL-6) levels, as these variables remained unaffected. The administration of dexpanthenol and thymoquinone has demonstrated notable neuroprotective effects in mitigating colistin-induced neurotoxicity in a rat model. A comparison of the neuroprotective properties of dexpanthenol and thymoquinone revealed that dexpanthenol had superior ameliorative effects on serum TAS and brain IL-6 levels compared to thymoquinone. The results of this study indicate that dexpanthenol may exhibit superior efficacy compared to thymoquinone in mitigating the neurotoxic adverse effects associated with colistin.

dexpanthenol和百里醌对粘菌素诱导的大鼠神经毒性的比较作用。
粘菌素被用作耐多药革兰氏阴性杆菌的最后一线治疗。神经毒性限制了粘菌素的临床应用。粘菌素的使用会引起氧化应激和炎症。葡萄糖醇和百里醌的抗氧化活性是众所周知的。本研究的目的是研究和比较糖醇和百里醌减轻大鼠受粘菌素治疗的神经毒性的效果。本研究使用酶联免疫吸附测定试剂盒研究炎症生物标志物,而使用几种光度法评估氧化应激生物标志物。用乙醇和百里醌治疗粘菌素神经毒性大鼠,采集其血清和脑组织样本。在大鼠中,给予葡聚糖醇可显著改善粘菌素诱导的氧化应激指标(血清二硫化物水平除外)和炎症生物标志物。百里醌的药效范围有限。除血清二硫水平、总抗氧化状态(TAS)和脑组织白细胞介素6 (IL-6)水平外,百里醌在用粘菌素处理的大鼠中显示出氧化应激和炎症指标的显著增强,因为这些变量未受影响。在大鼠模型中,dexpanthenol和thymo醌的管理在减轻粘菌素诱导的神经毒性方面显示出显着的神经保护作用。通过对dexpanthenol和百里醌的神经保护作用的比较发现,dexpanthenol对血清TAS和脑IL-6水平的改善作用优于百里醌。本研究结果表明,与百里醌相比,dexpanthenol在减轻粘菌素相关的神经毒性不良反应方面可能表现出优越的疗效。
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来源期刊
CiteScore
6.20
自引率
5.60%
发文量
142
审稿时长
4-8 weeks
期刊介绍: Naunyn-Schmiedeberg''s Archives of Pharmacology was founded in 1873 by B. Naunyn, O. Schmiedeberg and E. Klebs as Archiv für experimentelle Pathologie und Pharmakologie, is the offical journal of the German Society of Experimental and Clinical Pharmacology and Toxicology (Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie, DGPT) and the Sphingolipid Club. The journal publishes invited reviews, original articles, short communications and meeting reports and appears monthly. Naunyn-Schmiedeberg''s Archives of Pharmacology welcomes manuscripts for consideration of publication that report new and significant information on drug action and toxicity of chemical compounds. Thus, its scope covers all fields of experimental and clinical pharmacology as well as toxicology and includes studies in the fields of neuropharmacology and cardiovascular pharmacology as well as those describing drug actions at the cellular, biochemical and molecular levels. Moreover, submission of clinical trials with healthy volunteers or patients is encouraged. Short communications provide a means for rapid publication of significant findings of current interest that represent a conceptual advance in the field.
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