Susceptibility Patterns in Clinical Isolates of Mycobacterium avium Complex from a Hospital in Southern Spain.

IF 4.1 2区 生物学 Q2 MICROBIOLOGY
Adrián González Martínez, María Aguilera, María Tarriño, Ana Alberola, Juan Antonio Reguera, Antonio Sampedro, Jose María Navarro, Javier Rodríguez Granger
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Abstract

The incidence of infections caused by the Mycobacterium avium complex (MAC) has risen significantly, posing diagnostic and therapeutic challenges. This study analyzed 134 clinical isolates of the Mycobacterium avium complex from southern Spain, performing in vitro antimicrobial susceptibility testing using a commercial microdilution technique to generate additional data, refine treatment strategies, and improve patient outcomes. Phenotypic susceptibility testing revealed clarithromycin and amikacin as the most effective antibiotics, with susceptibility rates exceeding 90%, while linezolid and moxifloxacin exhibited limited activity, with resistance rates of 49.3% and 41.8%. A comparative analysis between M. avium and M. intracellulare showed significant differences in resistance to amikacin and linezolid, with M. avium exhibiting higher resistance rates. Additionally, species-specific differences were observed in MIC distributions for ethionamide, ciprofloxacin, and streptomycin. Our data reveal regional variability in resistance patterns, particularly for moxifloxacin and linezolid, which exhibit differing resistance rates compared to studies from other regions. The significant MIC differences for several antibiotics between M. avium and M. intracellulare underscore the importance of species-level identification and the heterogeneity in resistance mechanisms within MAC.

西班牙南部一家医院禽分枝杆菌复合体临床分离株的药敏模式
鸟分枝杆菌复合体(MAC)引起的感染发生率显著上升,给诊断和治疗带来挑战。本研究分析了来自西班牙南部的134株禽分枝杆菌复体临床分离株,使用商业微量稀释技术进行体外抗菌药敏试验,以产生额外数据,完善治疗策略,并改善患者预后。表型药敏试验显示克拉霉素和阿米卡星是最有效的抗生素,敏感性超过90%,而利奈唑胺和莫西沙星活性有限,耐药率分别为49.3%和41.8%。对比分析显示,鸟分枝杆菌和胞内分枝杆菌对阿米卡星和利奈唑胺的耐药率存在显著差异,鸟分枝杆菌的耐药率更高。此外,还观察到乙硫酰胺、环丙沙星和链霉素的MIC分布存在物种特异性差异。我们的数据揭示了耐药模式的区域差异,特别是莫西沙星和利奈唑胺,与其他地区的研究相比,它们的耐药率不同。鸟分枝杆菌和胞内分枝杆菌对几种抗生素的耐药性存在显著差异,这强调了物种水平鉴定和耐药性机制异质性的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microorganisms
Microorganisms Medicine-Microbiology (medical)
CiteScore
7.40
自引率
6.70%
发文量
2168
审稿时长
20.03 days
期刊介绍: Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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