Cryptosporidium Infection During Pregnancy and Effects on Pregnancy Outcomes in Israel.

IF 4.1 2区 生物学 Q2 MICROBIOLOGY
Shirley Shapiro Ben David, Olga Snitser, Miriam Parizade, Noam Orvieto, Yaacov Segal, Limor Adler
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Abstract

Cryptosporidium is a parasite that typically causes self-limited gastroenteritis. Little is known about the course of infection and its impact during pregnancy. This retrospective cohort study conducted in Israel assessed the effects of Cryptosporidium infection on pregnancy and obstetrical outcomes. The study population included pregnant women with a positive PCR stool test for Cryptosporidium and a control group of pregnant women with negative tests, matched at a 3:1 ratio based on age, gestational week, and sector. Their medical records were retrieved for symptoms, treatments, pregnancy termination, gestational age, birth weight, Apgar score, and head circumference. Fisher's exact or chi-squared tests were used to determine significance. Between January 2020 and December 2023, 2512 pregnant women underwent PCR stool testing. Of these, 93 were positive for Cryptosporidium, mostly in 2022. Their median age was 31 (range: 23-42 years), and 77.4% were from medium-high socioeconomic status. The most common symptom was diarrhea (90/93, 96.7%). The infection was self-limiting in all cases, with none requiring specific treatment. No significant differences were found in miscarriage rate, delivery week, birth weight, Apgar score, or head circumference compared to the controls. This study illuminates the clinical course of Cryptosporidium infection in pregnant women, emphasizing a generally favorable outcome without the necessity for therapeutic intervention.

以色列妊娠期隐孢子虫感染及其对妊娠结局的影响
隐孢子虫是一种寄生虫,通常会引起自限性肠胃炎。人们对感染的过程及其在怀孕期间的影响知之甚少。这项在以色列进行的回顾性队列研究评估了隐孢子虫感染对妊娠和产科结局的影响。研究人群包括PCR粪便检测隐孢子虫阳性的孕妇和检测阴性的对照组孕妇,根据年龄、孕周和部门按3:1的比例匹配。检索他们的医疗记录,包括症状、治疗、终止妊娠、胎龄、出生体重、Apgar评分和头围。使用Fisher精确检验或卡方检验来确定显著性。在2020年1月至2023年12月期间,2512名孕妇接受了PCR粪便检测。其中93例隐孢子虫呈阳性,大部分是在2022年。他们的中位年龄为31岁(范围:23-42岁),77.4%来自中高社会经济地位。最常见的症状是腹泻(90/93,96.7%)。所有病例的感染都是自限性的,没有人需要特殊治疗。与对照组相比,流产率、分娩周数、出生体重、Apgar评分或头围均无显著差异。本研究阐明了孕妇隐孢子虫感染的临床过程,强调了一个普遍有利的结果,而不需要治疗干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microorganisms
Microorganisms Medicine-Microbiology (medical)
CiteScore
7.40
自引率
6.70%
发文量
2168
审稿时长
20.03 days
期刊介绍: Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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