Effects of White Noise Intervention on Sleep Quality and Immunological Indicators of Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy.

IF 1.3 4区 医学 Q3 AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY
Noise & Health Pub Date : 2024-10-01 Epub Date: 2024-12-30 DOI:10.4103/nah.nah_111_24
Gang Yin, Na Li, Dan Xu, Zhen Meng, Shuyun Zheng, Ying Chen
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引用次数: 0

Abstract

Objective: Evaluate the effect of white noise intervention on sleep quality and immunological indicators of patients with breast cancer undergoing neoadjuvant chemotherapy (NAC).

Methods: From January 2020 to December 2022, 104 newly diagnosed female patients (the number of people who met the inclusion criteria) with breast cancer who were confirmed to be preoperative NAC by puncture pathology were selected for a randomised single-blind trial. The patients were randomly divided into an observation group and a control group, with 52 cases in each group. The control group of patients received routine NAC treatment. The observation group played white noise at regular intervals every night on the basis of routine NAC, covering the entire treatment cycle. We evaluated the clinical efficacy, safety, sleep quality and immunological indicators of the two groups.

Results: We found no statistically significant difference in the objective response rate between the two groups (P > 0.05). There was no statistically significant difference in the incidence of safety events between the two groups (P > 0.05). The total incidence of adverse reactions in the observation group was significantly lower than that in the control group (P < 0.05). After intervention, the sleep latency, subjective sleep quality, sleep duration, daytime function and sleep disorder scores of both groups decreased, and the observation group had significantly lower scores than the control group (P < 0.05). After intervention, both groups showed changes in immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM), C-reactive protein and serum interleukin-6, but the differences between the groups were not statistically significant (P > 0.05).

Conclusion: White noise intervention can improve the sleep quality of the NAC population with breast cancer and reduce the incidence of adverse reactions. In addition, it has no effect on the treatment efficacy, safety and immune indicators of patients.

白噪声干预对乳腺癌新辅助化疗患者睡眠质量及免疫指标的影响
目的:评价白噪声干预对乳腺癌新辅助化疗(NAC)患者睡眠质量及免疫指标的影响。方法:选取2020年1月至2022年12月104例经穿刺病理证实为术前NAC的新诊断女性乳腺癌患者(符合纳入标准的人数),进行随机单盲试验。将患者随机分为观察组和对照组,每组52例。对照组患者接受常规NAC治疗。观察组在常规NAC的基础上,每晚定时播放白噪声,覆盖整个治疗周期。对两组患者的临床疗效、安全性、睡眠质量及免疫指标进行评价。结果:两组客观有效率比较,差异无统计学意义(P < 0.05)。两组患者安全事件发生率比较,差异无统计学意义(P < 0.05)。观察组患者不良反应总发生率显著低于对照组(P < 0.05)。干预后,两组患者的睡眠潜伏期、主观睡眠质量、睡眠持续时间、日间功能、睡眠障碍评分均下降,且观察组得分显著低于对照组(P < 0.05)。干预后,两组患者免疫球蛋白A (IgA)、免疫球蛋白G (IgG)、免疫球蛋白M (IgM)、c反应蛋白及血清白介素-6均有变化,但组间差异无统计学意义(P < 0.05)。结论:白噪声干预可改善NAC人群乳腺癌患者的睡眠质量,减少不良反应的发生。此外,对患者的治疗疗效、安全性及免疫指标均无影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Noise & Health
Noise & Health AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
CiteScore
2.10
自引率
14.30%
发文量
27
审稿时长
6-12 weeks
期刊介绍: Noise and Health is the only International Journal devoted to research on all aspects of noise and its effects on human health. An inter-disciplinary journal for all professions concerned with auditory and non-auditory effects of occupational, environmental, and leisure noise. It aims to provide a forum for presentation of novel research material on a broad range of topics associated with noise pollution, its control and its detrimental effects on hearing and health. It will cover issues from basic experimental science through clinical evaluation and management, technical aspects of noise reduction systems and solutions to environmental issues relating to social and public health policy.
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