Safety and Effectiveness of a New 532 nm, Long Pulse-Duration, Variable Pulse Structure Laser for Treatment of Poikiloderma of Civatte

IF 2.2 3区医学 Q2 DERMATOLOGY

Lasers in Surgery and Medicine Pub Date : 2025-01-09 DOI:10.1002/lsm.23881

Eric F. Bernstein, Jennifer Wang, Chelsea Eason

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引用次数: 0

Abstract

Background

Poikiloderma of Civatte is a benign skin condition characterized by reticulate erythema and hyperpigmentation in sun-exposed areas, predominantly on the neck, cheeks, and chest. Chronic UV exposure leads to vascular proliferation and red cell extravasation resulting in hemosiderin and melanin deposition. While many light-based modalities have been utilized to treat the disorder, the significant vascularity makes it ideally suited for treatment with vascular lasers.

Objective

This study aims to evaluate the safety and efficacy of a new, long-pulse-duration, Nd:YAG laser incorporating a KTP frequency-doubling crystal and cryogen spray cooling for the treatment of Poikiloderma of Civatte.

Methods

Twenty subjects with neck and/or chest redness were enrolled in this study and treated using the 532 nm wavelength to treat neck and chest redness. Four treatments were administered at monthly intervals and pre- and 2-month posttreatment images were obtained. Images were randomized and evaluated by three physician evaluators for degree of improvement.

Results

Average improvement 2-months posttreatment were 74.1 ± 20.2% and 68.4 ± 20.5% for the neck and chest, respectively (p < 0.0001). Side effects were minimal and limited to posttreatment erythema, edema, and purpura.

Conclusions

This study demonstrates that this new long pulse-duration, Nd:YAG laser incorporating a KTP frequency-doubling crystal using the 532 nm wavelength is safe and effective for the treatment of Poikiloderma of Civatte.

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新型532 nm长脉冲持续时间可变脉冲结构激光器治疗猫千皮病的安全性和有效性。

背景：Civatte白千皮病是一种良性皮肤病，其特征是网状红斑和色素沉着，主要发生在颈部、脸颊和胸部。慢性紫外线照射导致血管增生和红细胞外渗，导致含铁血黄素和黑色素沉积。虽然许多基于光的方式已被用于治疗这种疾病，但显著的血管性使其非常适合血管激光治疗。目的：本研究旨在评价一种新型长脉冲持续Nd:YAG激光结合KTP倍频晶体和冷冻剂喷雾冷却治疗紫千皮病的安全性和有效性。方法：选取20例颈部和/或胸部发红的受试者，采用532 nm波长治疗颈部和胸部发红。每隔一个月进行四次治疗，获得治疗前和治疗后2个月的图像。图像随机化，并由三名医师评估改善程度。结果：治疗2个月后，颈部和胸部的平均改善率分别为74.1±20.2%和68.4±20.5% (p)结论：本研究表明，采用532 nm波长的新型长脉冲持续Nd:YAG激光结合KTP倍频晶体治疗奇瓦特白千皮病是安全有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Lasers in Surgery and Medicine 医学-外科

CiteScore

5.40

自引率

12.50%

发文量

119

审稿时长

1 months

期刊介绍： Lasers in Surgery and Medicine publishes the highest quality research and clinical manuscripts in areas relating to the use of lasers in medicine and biology. The journal publishes basic and clinical studies on the therapeutic and diagnostic use of lasers in all the surgical and medical specialties. Contributions regarding clinical trials, new therapeutic techniques or instrumentation, laser biophysics and bioengineering, photobiology and photochemistry, outcomes research, cost-effectiveness, and other aspects of biomedicine are welcome. Using a process of rigorous yet rapid review of submitted manuscripts, findings of high scientific and medical interest are published with a minimum delay.