Different daily times for at-home bleaching with 10% carbamide peroxide

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of the American Dental Association Pub Date : 2025-01-01 DOI:10.1016/j.adaj.2024.10.010

Renata Maria Oleniki Terra DDS, MS, PhD, Elisama Sutil DDS, MS, PhD, Deisy Cristina Ferreira Cordeiro DDS, MS, Michael Willian Favoreto DDS, MS, PhD, André Faria-e-Silva DDS, MS, PhD, Al M. Best PhD, Alessandro D. Loguercio DDS, MS, PhD, Alessandra Reis DDS, PhD

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引用次数: 0

Abstract

Background

This single-blind, noninferiority trial evaluated whether 10% carbamide peroxide (CP) applied for 2 or 4 hours daily is noninferior to 8 hours.

Methods

A total of 120 healthy adults, with teeth shade A2 or darker, were randomly allocated to 3 groups (n = 40). All participants used 10% CP gel in a bleaching tray for 2, 4, and 8 hours daily for 14 days, with the option to extend treatment if they were dissatisfied. Color change was measured using a spectrophotometer and shade guides at baseline, every 5 days, and 1 month posttreatment. Risk and intensity of tooth sensitivity (TS) were assessed daily using a 0 through 10 visual analog scale. Satisfaction was recorded via a Likert scale wherein 1 corresponded to very dissatisfied and 7 corresponded to very satisfied and the Orofacial Esthetic Scale. Noninferiority was tested for color change using the 1976 formula (ΔEab) at 1 month postbleaching (primary outcome), color change using the 2000 formula (ΔE00), Whiteness Index, and shade guide units, whereas TS and satisfaction were analyzed with χ², analysis of variance, Kruskal-Wallis, and Friedman tests.

Results

Color change in ΔEab (2 vs 8 h: mean difference, −0.6; 90% CI, −2.1 to 1.0, 4 vs 8 h: mean difference, 0.0; 90% CI, −1.6 to 1.6) and ΔE00 values for shorter durations were noninferior to 8 hours at 1 month. Whiteness Index results were inconclusive. TS risk and intensity were similar (P > .05), and patient satisfaction improved across all groups similarly (P > .05).

Conclusions

Shorter 2- and 4-hour daily bleaching with 10% CP is noninferior to the 8-hour protocol.

Practical Implications

Shorter periods of at-home bleaching (2 and 4 h) can be prescribed depending on the patient's availability or preferences without jeopardizing the bleaching efficacy. This clinical trial was registered at Registro Brasileiro de Ensaios Clínicos (RBR-10vvfpcm).

查看原文本刊更多论文

10%过氧化脲在家中漂白的不同每日次数：一项随机、单盲、非劣效性对照试验。

背景：这项单盲、非劣效性试验评估了10%过氧化脲（CP）每日应用2小时或4小时是否优于8小时。方法：健康成人120例，牙色A2或更深，随机分为3组（n = 40）。所有参与者在漂白托盘中每天使用10% CP凝胶2、4和8小时，持续14天，如果他们不满意，可以选择延长治疗时间。在基线、每5天和治疗后1个月，使用分光光度计和阴影指南测量颜色变化。每天使用0到10的视觉模拟量表评估牙齿敏感（TS）的风险和强度。满意度是通过李克特量表记录的，其中1代表非常不满意，7代表非常满意和口腔面部美学量表。使用1976公式（ΔEab）对漂白后1个月（主要结局）的颜色变化进行非劣效性检验，使用2000公式（ΔE00）、白度指数和色度指导单位对颜色变化进行检验，而使用χ2、方差分析、Kruskal-Wallis和Friedman检验对TS和满意度进行分析。结果：ΔEab颜色变化(2 vs 8 h：平均差值-0.6；90% CI, -2.1至1.0,4 vs 8 h：平均差值，0.0；90% CI, -1.6至1.6)和ΔE00值在1个月时较短的持续时间不低于8小时。白度指数结果不确定。TS风险和强度相似（P < 0.05），患者满意度在所有组中均有相似的改善（P < 0.05）。结论：较短的每日2小时和4小时漂白，10% CP不低于8小时方案。实际意义：在不影响漂白效果的情况下，可根据患者的可用性或偏好规定较短的居家漂白时间（2和4小时）。该临床试验已在Registro Brasileiro de enaios Clínicos （RBR-10vvfpcm）注册。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Dental Association 医学-牙科与口腔外科

CiteScore

5.30

自引率

10.30%

发文量

221

审稿时长

34 days

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