Sustained quality-of-life improvements over 10 years after subthalamic nucleus deep brain stimulation for isolated dystonia.

IF 4.8 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology Pub Date : 2025-01-07 DOI:10.1007/s00415-024-12820-4

Shaoyi Zhang, Yanjing Li, Dian Chen, Hongxia Li, Tao Wang, Peng Huang, Tienan Feng, Bomin Sun, Dianyou Li, Suzhen Lin, Yiwen Wu

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引用次数: 0

Abstract

Background: Bilateral deep brain stimulation (DBS) of subthalamic nucleus (STN) has demonstrated efficacy for ameliorating medication-refractory isolated dystonia. Nonetheless, the paucity of evidence regarding its long-term impact on quality-of-life (QoL) necessitates further investigation.

Objectives: This study aimed to elucidate the longitudinal effects of chronic STN stimulation on QoL in patients suffering from isolated dystonia.

Methods: We enrolled 54 subjects diagnosed with isolated dystonia who underwent STN-DBS and maintained post-operative status for over 5 years. The 36-item Short Form General Health Survey (SF-36) assessed QoL, while the Montreal Cognitive Assessment (MoCA) evaluated cognitive functioning.

Results: The average follow-up since implantation extended to 10.9 years. The data analysis revealed a significant enhancement in QoL following STN-DBS treatment, as Physical Component Summary (PCS), Mental Component Summary (MCS), and Global scores demonstrated substantial improvement from pre-DBS to post-DBS (p < 0.0001). The disease classifications yielded differential results; patients with generalized dystonia exhibited superior improvements in PCS (p = 0.0053) and Global scores (p = 0.0120) compared to other types. Patients aged < 36 at the time of implantation experienced greater improvements in PCS (p = 0.0109) and global scores (p = 0.0057) than older counterparts. Cognitive function, as per the MoCA scale, showed no significant difference between pre- and post-operative scores (p = 0.08).

Conclusions: STN-DBS appears to confer enduring improvements to the QoL in dystonia patients, persisting an average of 10 years or more post-surgery. These findings underscore the long-term efficacy of STN-DBS for isolated dystonia and highlight the influence of patient age and disease classification on outcomes.

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来源期刊

Journal of Neurology 医学-临床神经学

CiteScore

10.00

自引率

5.00%

发文量

558

审稿时长

1 months

期刊介绍： The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.