Raul E Sanchez, Elizabeth Reichard, Adam Bobbey, Neetu Bali Puri, Peter L Lu, Desale Yacob, Carlo Di Lorenzo, Kent Williams, Karla K H Vaz
{"title":"Delayed Gastric Emptying Correlates With Decreased Post-prandial Motility in Children: A Single-center Retrospective Review.","authors":"Raul E Sanchez, Elizabeth Reichard, Adam Bobbey, Neetu Bali Puri, Peter L Lu, Desale Yacob, Carlo Di Lorenzo, Kent Williams, Karla K H Vaz","doi":"10.5056/jnm24057","DOIUrl":null,"url":null,"abstract":"<p><strong>Background/aims: </strong>Pediatric patients with suspected gastroparesis often undergo antroduodenal manometry (ADM) and gastric emptying scintigraphy (GES) for diagnostic purposes. However, it is unknown if delayed gastric emptying (DGE) correlates with manometric findings. This study evaluates whether ADM parameters differ between normal and abnormal GES in pediatric patients.</p><p><strong>Methods: </strong>Data from pediatric patients undergoing ADM and GES at Nationwide Children's Hospital from 2011-2020 were retrospectively reviewed. Manometry parameters including motility index (Ln [sum of amplitudes × number of contractions + 1]), number of antral contractions, and direction of the phase III migrating motor complex (MMC) were compared to GES results from age-matched patients with DGE (n = 32) and normal gastric emptying (NGE) (n = 32) of similar sex, body mass index, and weight.</p><p><strong>Results: </strong>Children with DGE had a lower post-prandial antral motility index and antral contraction number than those with NGE (9.4 vs 11.2, <i>P</i> = 0.005; 21.8 vs 49.6, <i>P</i> < 0.001). The gastric emptying percentage at 4 hours was lower in patients with retrograde phase III (59.2% vs 83.9%, <i>P</i> = 0.022) and in those without an antral component in the fasting phase III of the migrating motor complex (70.3% vs 86.5%, <i>P</i> = 0.003). Post-prandial antral hypomotility occurred more frequently in the DGE group than in the NGE group (41% vs 9%, <i>P</i> = 0.008).</p><p><strong>Conclusions: </strong>ADM findings differ between children with DGE and NGE. Children with DGE are more likely to have abnormal fasting phase III patterns and decreased post-prandial antral activity during ADM testing.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"31 1","pages":"102-109"},"PeriodicalIF":3.3000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735193/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurogastroenterology and Motility","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5056/jnm24057","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background/aims: Pediatric patients with suspected gastroparesis often undergo antroduodenal manometry (ADM) and gastric emptying scintigraphy (GES) for diagnostic purposes. However, it is unknown if delayed gastric emptying (DGE) correlates with manometric findings. This study evaluates whether ADM parameters differ between normal and abnormal GES in pediatric patients.
Methods: Data from pediatric patients undergoing ADM and GES at Nationwide Children's Hospital from 2011-2020 were retrospectively reviewed. Manometry parameters including motility index (Ln [sum of amplitudes × number of contractions + 1]), number of antral contractions, and direction of the phase III migrating motor complex (MMC) were compared to GES results from age-matched patients with DGE (n = 32) and normal gastric emptying (NGE) (n = 32) of similar sex, body mass index, and weight.
Results: Children with DGE had a lower post-prandial antral motility index and antral contraction number than those with NGE (9.4 vs 11.2, P = 0.005; 21.8 vs 49.6, P < 0.001). The gastric emptying percentage at 4 hours was lower in patients with retrograde phase III (59.2% vs 83.9%, P = 0.022) and in those without an antral component in the fasting phase III of the migrating motor complex (70.3% vs 86.5%, P = 0.003). Post-prandial antral hypomotility occurred more frequently in the DGE group than in the NGE group (41% vs 9%, P = 0.008).
Conclusions: ADM findings differ between children with DGE and NGE. Children with DGE are more likely to have abnormal fasting phase III patterns and decreased post-prandial antral activity during ADM testing.
背景/目的：疑似胃轻瘫的儿童患者经常接受十二指肠压力测量（ADM）和胃排空显像（GES）进行诊断。然而，尚不清楚胃排空延迟（DGE）是否与压力测量结果相关。本研究评估小儿GES正常与异常患者的ADM参数是否存在差异。方法：回顾性分析2011-2020年在全国儿童医院接受ADM和GES治疗的儿童患者的资料。将压力测量参数包括运动指数（Ln[振幅总和×收缩次数+ 1]）、胃窦收缩次数和III期运动复核（MMC）方向与年龄匹配的性别、体重指数和体重相似的DGE患者（n = 32）和正常胃排空（NGE）患者（n = 32）的GES结果进行比较。结果：DGE患儿餐后心窦运动指数和心窦收缩次数均低于NGE患儿(9.4 vs 11.2, P = 0.005；21.8 vs 49.6, P < 0.001)。逆行III期患者的4小时胃排空率较低（59.2% vs 83.9%, P = 0.022），而在迁移运动复合物的禁食III期中没有胃窦成分的患者（70.3% vs 86.5%, P = 0.003）。餐后胃窦功能低下在DGE组的发生率高于NGE组（41% vs 9%, P = 0.008）。结论：DGE和NGE患儿的ADM结果不同。在ADM测试中，DGE患儿更有可能出现异常的空腹III期模式和餐后心房活动下降。
期刊介绍：
Journal of Neurogastroenterology and Motility (J Neurogastroenterol Motil) is a joint official journal of the Korean Society of Neurogastroenterology and Motility, the Thai Neurogastroenterology and Motility Society, the Japanese Society of Neurogastroenterology and Motility, the Indian Motility and Functional Disease Association, the Chinese Society of Gastrointestinal Motility, the South East Asia Gastro-Neuro Motility Association, the Taiwan Neurogastroenterology and Motility Society and the Asian Neurogastroenterology and Motility Association, launched in January 2010 after the title change from the Korean Journal of Neurogastroenterology and Motility, published from 1994 to 2009.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
