Association of small vessel disease progression with longitudinal cognitive decline across mild cognitive impairment.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-01-10 DOI:10.1177/13872877241305800

Jingru Wang, Asta Debora, Lixuan Chen, Haisong Chen, Xuemiao Zhao, Mengying Yu, Yunjun Yang

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引用次数: 0

Abstract

Background: Cerebral small vessel disease (SVD) is the leading cause of vascular dementia. However, it is unclear whether the individual SVD or global SVD progression correlates with cognitive decline across mild cognitive impairment (MCI) subjects.

Objective: To investigate the association of small vessel disease progression with longitudinal cognitive decline across MCI.

Methods: We included 432 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, with 151 participants in the cognitively normal (CN) group and 281 participants in the MCI group. We evaluated magnetic resonance imaging-based SVD markers in both CN and MCI groups and explored their associations with 12-and 24-month cognitive decline using linear mixing effect (LME) models.

Results: In the CN group, cerebral microbleed (CMB) progression was associated with the decline in language function (p < 0.05), and deep white matter hyperintensity (WMH) progression was associated with a decline in memory function (p < 0.05). In the MCI group, CMB progression was associated with a decline in memory function (p < 0.05) and lacunes progression was associated with executive function (p < 0.05), whereas the progression of global SVD score was not related to longitudinal cognitive function.

Conclusions: The progression of CMB and WMH had an impact on cognitive decline in both CN and MCI groups, and lacunes progression only had an association with cognitive decline in the MCI group. Our study suggested that individual SVD markers may have a higher predictive value in longitudinal cognition compared with global SVD burden.

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轻度认知障碍患者小血管疾病进展与纵向认知能力下降的关系

背景：脑血管病（SVD）是血管性痴呆的主要原因。然而，目前尚不清楚个体SVD或整体SVD进展是否与轻度认知障碍（MCI）受试者的认知能力下降相关。目的：探讨小血管疾病进展与MCI纵向认知能力下降的关系。方法：我们从阿尔茨海默病神经影像学倡议（ADNI）数据库中纳入432名参与者，其中认知正常（CN）组151名参与者，MCI组281名参与者。我们在CN和MCI组中评估了基于磁共振成像的SVD标记物，并使用线性混合效应（LME）模型探讨了它们与12个月和24个月认知能力下降的关系。结果：在CN组，脑微出血（CMB）进展与语言功能下降有关(p结论：CMB和WMH进展对CN组和MCI组的认知能力下降均有影响，而凹窝进展仅与MCI组的认知能力下降有关。我们的研究表明，与整体SVD负担相比，个体SVD标记物在纵向认知方面可能具有更高的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.