The effects of transcranial direct current stimulation on global cognition in patients with Alzheimer's disease: An update meta-analysis.

IF 3.4 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI:10.1177/13872877241298303

Siyuan Su, Ruihan Huang, Yongsheng Liu

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引用次数: 0

Abstract

Background: Alzheimer's disease (AD) is a neurodegenerative disease. At present, there are currently no drugs that can cure AD.

Objective: A number of empirical studies have shown that transcranial direct current stimulation (tDCS) may be used to treat cognitive abnormalities in patients with AD. We will through meta-analysis reviews tDCS overall research on the effects of cognitive function in patients with AD.

Methods: Systematic searches were performed in the PubMed, Embase, and Cochrane Library databases from their creation until 8 March 2024. Using a fixed effect model and random effect model to evaluate the average difference between the treatment group and control group (MD) and its 95% confidence interval (CI).

Results: The study included 10 randomized controlled trials (Nactive = 165, Nsham = 167). The results of the overall analysis showed that tDCS did not significantly improve the overall cognitive function (SMD = 0.17; 95%CI = -0.05, 0.39; p = 0.14; I² = 51%). Quality of life of AD patients after treatment was also evaluated, but no improvement was seen. Subgroup analysis showed no significant improvement in global cognitive function after tDCS treatment. The sensitivity analysis to confirm the reliability of the data, risk assessment did not find any high-risk projects.

Conclusions: The tDCS treatment did not improve cognitive function in patients with AD. Further empirical research in the future will help to explore new schemes for tDCS to improve cognitive function of patients.

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经颅直流电刺激对阿尔茨海默病患者整体认知的影响：一项最新荟萃分析

背景：阿尔茨海默病（AD）是一种神经退行性疾病。目前，还没有能够治愈AD的药物。目的：大量实证研究表明，经颅直流电刺激（tDCS）可用于治疗AD患者的认知异常。我们将通过荟萃分析回顾tDCS对AD患者认知功能影响的总体研究。方法：系统检索PubMed， Embase和Cochrane图书馆数据库，从其创建到2024年3月8日。采用固定效应模型和随机效应模型评价治疗组与对照组的平均差异（MD）及其95%置信区间（CI）。结果：纳入10项随机对照试验（Nactive = 165, Nsham = 167）。综合分析结果显示，tDCS对整体认知功能无显著改善(SMD = 0.17；95%ci = -0.05, 0.39；p = 0.14；i²= 51%)。对治疗后AD患者的生活质量也进行了评估，但没有发现改善。亚组分析显示，tDCS治疗后整体认知功能无显著改善。通过敏感性分析确认了数据的可靠性，风险评估中未发现任何高风险项目。结论：tDCS治疗不能改善AD患者的认知功能。未来进一步的实证研究将有助于探索tDCS改善患者认知功能的新方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.