Clinical efficacy of OS-01 peptide formulation in reducing the signs of periorbital skin aging.

IF 2.7 4区医学 Q2 DERMATOLOGY

International Journal of Cosmetic Science Pub Date : 2025-01-09 DOI:10.1111/ics.13042

Alessandra Zonari, Lear E Brace, Fanghua Li, Nathaniel H O Harder, Claire Harker, Carolyn Jacob, Joely Kaufman, Suneel Chilukuri, Carolina R Oliveira, Mariana Boroni, Juliana L Carvalho

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引用次数: 0

Abstract

Background: The aging of the skin, particularly around the periorbital region, is a complex process characterized by the accumulation of senescent cells, decreased collagen production, and reduced skin elasticity, leading to visible signs such as fine lines, wrinkles, and sagging.

Objective: This study investigates the efficacy of a novel topical formulation, OS-01 EYE, containing the senomorphic peptide, OS-01, along with other active ingredients, in improving the skin around the eyes.

Methods: A 12-week clinical study was conducted with 22 participants who applied OS-01 EYE twice daily. Assessments included bioinstrumental measurements of skin hydration, barrier function, firmness, and elasticity, as well as expert photographs grading fine lines, wrinkles, under-eye puffiness, and dark circles.

Results: After 12 weeks of product use, transepidermal water loss (TEWL) decreased by 17.33%, hydration increased by 32.49%, skin firmness improved by 10.19%, and elasticity increased by 25.58%, compared to baseline, which was all statistically significant. Expert grading revealed a decrease in fine lines and wrinkles, under-eye puffiness, and dark circles over the study period. Furthermore, subjective assessments showed that 95.46% of participants reported improvements in overall appearance.

Conclusion: The OS-01 EYE formulation was found to be safe and effective in mitigating the visible signs of aging in the periorbital region, making it a potent treatment option for enhancing periorbital skin health, function, and appearance.

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OS-01肽制剂减轻眶周皮肤衰老征象的临床疗效观察。

背景：皮肤的老化，特别是眼眶周围的皮肤，是一个复杂的过程，其特征是衰老细胞的积累，胶原蛋白的产生减少，皮肤弹性降低，导致细纹，皱纹和下垂等可见迹象。目的：本研究探讨了一种新型外用制剂OS-01 EYE的功效，该制剂含有OS-01肽以及其他活性成分，可改善眼周皮肤。方法：22名参与者进行了为期12周的临床研究，每天两次应用OS-01 EYE。评估包括皮肤水合、屏障功能、紧致度和弹性的生物仪器测量，以及细纹、皱纹、眼下浮肿和黑眼圈的专家照片分级。结果：产品使用12周后，经皮失水（TEWL）较基线降低17.33%，水合性提高32.49%，皮肤紧致度提高10.19%，弹性提高25.58%，差异均有统计学意义。专家评分显示，在研究期间，细纹、皱纹、眼袋和黑眼圈都有所减少。此外，主观评估显示，95.46%的参与者报告整体外观有所改善。结论：OS-01 EYE配方安全有效地缓解了眼窝周围区域的明显老化迹象，使其成为增强眼窝周围皮肤健康、功能和外观的有效治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Cosmetic Science DERMATOLOGY-

CiteScore

4.60

自引率

4.30%

发文量

期刊介绍： The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.