Tissue Eosinophils Threshold and its Association with Adult-Onset Asthma in Chronic Rhinosinusitis.

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY

International Forum of Allergy & Rhinology Pub Date : 2025-01-08 DOI:10.1002/alr.23527

Patlada Kowatanamongkon, Kornkiat Snidvongs, Potjanee Korrungruang, Nutpacha Chotikawichean, Dichapong Kanjanawasee, Kittichai Mongkolkul, Wirach Chitsuthipakorn

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引用次数: 0

Abstract

Introduction: Tissue eosinophil counts (TEC) might serve as a biomarker linking chronic rhinosinusitis (CRS) and the presence of adult-onset asthma. This study aimed to determine if TEC in sinus mucosa/polyps in CRS patients is an independent indicator of asthma and to identify its optimal cut-off point.

Methods: This cross-sectional study was conducted on primary CRS patients scheduled for surgery. All patients were assessed by a pulmonologist for asthma diagnosis. Tissues were collected during surgery and evaluated for TEC. Logistic regression and receiver operating characteristic analysis were used to determine significant factors and the optimal cut-off points of TEC associated with asthma.

Results: A total of 103 CRS patients were included. Ten patients (9.7%) had underlying asthma, while 13 (12.6%) were first diagnosed by the pulmonologist. TEC ≥40 cells per high-powered field (HPF) exhibited a significant correlation with asthma (area under the curve = 0.71, p < 0.001). The sensitivity of this cut-off point was 0.70 (95% confidence interval [CI] = 0.47-0.87), and specificity was 0.66 (95% CI = 0.55-0.76). Positive predictive value and negative predictive value were 0.37 and 0.88, respectively. The cut-off point significantly associated with the presence of asthma, with an adjusted odds ratio of 3.13 (95% CI = 1.05-9.35, p = 0.04), controlling for polyps, allergic rhinitis, and computerized tomography (CT) score.

Conclusion: TEC in CRS patients can help determine the presence of adult-onset asthma, with an optimal threshold of ≥40 cells/HPF. This threshold is significantly associated with asthma independent of polyps, allergy, and CT score.

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组织嗜酸性粒细胞阈值及其与慢性鼻窦炎成人发病哮喘的关系。

组织嗜酸性粒细胞计数（TEC）可能作为连接慢性鼻窦炎（CRS）和成人发作哮喘存在的生物标志物。本研究旨在确定CRS患者窦黏膜/息肉TEC是否为哮喘的独立指标，并确定其最佳分界点。方法：本横断面研究对计划手术的原发性CRS患者进行。所有患者均由肺病专家评估哮喘诊断。术中收集组织并评估TEC。采用Logistic回归和受试者工作特征分析确定TEC与哮喘相关的显著因素和最佳临界值。结果：共纳入103例CRS患者。10例患者（9.7%）有潜在哮喘，13例患者（12.6%）首次由肺病专家诊断。TEC≥40个细胞/高倍视野（high-powered field， HPF）与哮喘有显著相关性（曲线下面积= 0.71,p）。结论：CRS患者的TEC可帮助判断成人发病哮喘的存在，最佳阈值为≥40个细胞/HPF。该阈值与哮喘显著相关，与息肉、过敏和CT评分无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.