Application of Mendelian randomization analysis to explore causal associations of aspirin use with bone mineral density and risk of fracture.

IF 2.7 3区 生物学
Qi-Pei Liu
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引用次数: 0

Abstract

Objective: Previous observational studies on the association between aspirin use, bone mineral density (BMD), and fracture risk have yielded controversial results. This study explored the causal relationship between aspirin use, BMD, and fracture risk using Mendelian randomization (MR).

Methods: Summary data for aspirin use and BMD of five different body parts (femoral neck, lumbar spine, forearm, heel, and ultra distal forearm) and fractures were obtained from the integrative epidemiology unit open genome-wide association studies database for bidirectional MR analysis. An appropriate model was chosen based on Cochran's Q test, with inverse variance-weighted as the primary method for MR analysis, supplemented by the weighted-median and MR-Egger methods. MR-Egger and MR-PRESSO were used to test for horizontal pleiotropy and exclude significant outliers that could bias the results. Various sensitivity analyses, including leave-one-out analysis, were conducted to ensure the robustness of the findings.

Results: Aspirin use significantly increased lumbar spine BMD (odds ratio [OR] = 4.660; 95% confidence interval [CI]: 1.365-15.906; P = 0.014). No significant causal association was found between aspirin use and fracture risk (beta = 59.951; 95% CI: -265.189-385.091; P = 0.718). No significant reverse causality was observed.

Conclusion: This study indicates that aspirin use does not significantly affect fracture risk but has a significant protective effect on lumbar spine BMD, revealing a potential benefit of aspirin against osteoporosis.

应用孟德尔随机化分析探讨阿司匹林与骨密度和骨折风险的因果关系。
目的:先前关于阿司匹林使用、骨密度(BMD)和骨折风险之间关系的观察性研究得出了有争议的结果。本研究采用孟德尔随机化(MR)方法探讨阿司匹林使用、骨密度和骨折风险之间的因果关系。方法:从综合流行病学单位开放全基因组关联研究数据库中获取阿司匹林使用和五个不同身体部位(股骨颈、腰椎、前臂、足跟和前臂超远端)和骨折的BMD的汇总数据,用于双向MR分析。根据Cochran’s Q检验选择合适的模型,MR分析以方差反加权法为主,加权中位数法和MR- egger法为辅。使用MR-Egger和MR-PRESSO来测试水平多效性,并排除可能导致结果偏差的显著异常值。进行了各种敏感性分析,包括遗漏分析,以确保研究结果的稳健性。结果:阿司匹林显著增加腰椎骨密度(优势比[OR] = 4.660;95%置信区间[CI]: 1.365-15.906;p = 0.014)。阿司匹林的使用与骨折风险之间没有明显的因果关系(β = 59.951;95% ci: -265.189-385.091;p = 0.718)。未观察到显著的反向因果关系。结论:本研究提示阿司匹林对骨折风险无显著影响,但对腰椎骨密度有显著保护作用,提示阿司匹林对骨质疏松症有潜在益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hereditas
Hereditas Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.80
自引率
3.70%
发文量
0
期刊介绍: For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.
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