{"title":"Mapping the research landscape of microRNAs in pain: a comprehensive bibliometric analysis.","authors":"Huaiming Wang, Qin Li, Jiang Zou, Jinjun Shu, Aimin Zhang, Hongwei Zhang, Qi Zhao, Shunxin Liu, Chan Chen, Guo Chen","doi":"10.3389/fnmol.2024.1493822","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objectives: </strong>MicroRNAs (miRNAs) have demonstrated significant potential in pain medicine research, including mechanisms, diagnosis, and therapy. However, no relative bibliometric analysis has been performed to summarize the progress in this area quantitatively.</p><p><strong>Methods: </strong>Literature was retrieved from the Web of Science Core Collection online database. A total of 1,295 papers were retrieved between January 1, 2000 and September 21, 2023 and underwent visualization and analysis using R software [Library [bibliometrix] and biblioshiny packages], VOSviewer (version 1.6.18), CiteSpace software (version 6.2.R4), and the bibliometrics website (http://bibliometric.com).</p><p><strong>Results: </strong>Publications in this field have increased annually since 2000, demonstrating growing research interest. China emerged as the most productive country, followed by the United States and Germany. Keyword analysis identified \"expression,\" \"neuropathic pain,\" and \"microRNAs\" as the most relevant keywords. Extensive collaboration among countries and institutions was also observed.</p><p><strong>Conclusion: </strong>The bibliometric analysis revealed a rapid growth of publications related to miRNAs and pain in the past 2 decades. Keywords analysis indicates that \"expression,\" \"neuropathic pain,\" and \"microRNA\" are the most frequently used words in this research field. However, more robust and globally recognized basic studies and clinical trials from prestigious journals are required.</p>","PeriodicalId":12630,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"17 ","pages":"1493822"},"PeriodicalIF":3.5000,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703907/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Molecular Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnmol.2024.1493822","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objectives: MicroRNAs (miRNAs) have demonstrated significant potential in pain medicine research, including mechanisms, diagnosis, and therapy. However, no relative bibliometric analysis has been performed to summarize the progress in this area quantitatively.
Methods: Literature was retrieved from the Web of Science Core Collection online database. A total of 1,295 papers were retrieved between January 1, 2000 and September 21, 2023 and underwent visualization and analysis using R software [Library [bibliometrix] and biblioshiny packages], VOSviewer (version 1.6.18), CiteSpace software (version 6.2.R4), and the bibliometrics website (http://bibliometric.com).
Results: Publications in this field have increased annually since 2000, demonstrating growing research interest. China emerged as the most productive country, followed by the United States and Germany. Keyword analysis identified "expression," "neuropathic pain," and "microRNAs" as the most relevant keywords. Extensive collaboration among countries and institutions was also observed.
Conclusion: The bibliometric analysis revealed a rapid growth of publications related to miRNAs and pain in the past 2 decades. Keywords analysis indicates that "expression," "neuropathic pain," and "microRNA" are the most frequently used words in this research field. However, more robust and globally recognized basic studies and clinical trials from prestigious journals are required.
期刊介绍：
Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.
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