Immunohistochemical insights into hypothermia-related deaths: a systematic review.

IF 1.5 4区医学 Q2 MEDICINE, LEGAL

Forensic Science, Medicine and Pathology Pub Date : 2025-01-09 DOI:10.1007/s12024-024-00934-0

Luca Tomassini, Massimo Lancia, Cristiana Gambelunghe, Giulia Ricchezze, Piergiorgio Fedeli, Mariano Cingolani, Francesco De Micco, Elena Fiorucci, Roberto Scendoni

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引用次数: 0

Abstract

Purpose: Hypothermia occurs when core body temperature drops below 35 °C. The purpose of this review was to identify and analyze studies on the topic of hypothermia from an immunohistochemical perspective to determine robust markers of fatal hypothermia.

Methods: This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. It has been registered with Prospero (registration number: CRD42024572782).

Results: In total, 2618 publications met the search criteria. A total of 63 duplicate articles were excluded and a further 2489 publications were excluded for not meeting the inclusion criteria, leaving 29 full-text articles. Furthermore, from the bibliographies of the included articles, four more publications were selected, which also respected the established inclusion and exclusion criteria. Only six studies identified a statistically significant correlation between immunohistochemical patterns and hypothermia-related deaths.

Conclusion: The existing literature examined appears fragmented and lacks robust statistical validation. Therefore, there is an evident need for more comprehensive and methodologically rigorous research to develop reliable diagnostic criteria.

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来源期刊

Forensic Science, Medicine and Pathology MEDICINE, LEGAL-PATHOLOGY

CiteScore

3.90

自引率

5.60%

发文量

114

审稿时长

6-12 weeks

期刊介绍： Forensic Science, Medicine and Pathology encompasses all aspects of modern day forensics, equally applying to children or adults, either living or the deceased. This includes forensic science, medicine, nursing, and pathology, as well as toxicology, human identification, mass disasters/mass war graves, profiling, imaging, policing, wound assessment, sexual assault, anthropology, archeology, forensic search, entomology, botany, biology, veterinary pathology, and DNA. Forensic Science, Medicine, and Pathology presents a balance of forensic research and reviews from around the world to reflect modern advances through peer-reviewed papers, short communications, meeting proceedings and case reports.