Change in fatigue in patients with ulcerative colitis or Crohn's disease initiating biologic therapy.

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Digestive and Liver Disease Pub Date : 2025-01-08 DOI:10.1016/j.dld.2024.12.011

Edouard Louis, Peter Bossuyt, Arnaud Colard, Antoine Nakad, Didier Baert, Fazia Mana, Philip Caenepeel, Stijn Vanden Branden, Severine Vermeire, Francois D'Heygere, Beatrijs Strubbe, Anneline Cremer, Vida Setakhr, Filip Baert, Anne Vijverman, Jean-Louis Coenegrachts, Frederic Flamme, Anke Hantson, Jie Zhou, Geert Van Gassen

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引用次数: 0

Abstract

Background: Fatigue is common among patients with inflammatory bowel diseases (IBDs) and is associated with decreased quality of life (QoL).

Aims: Describe fatigue evolution and identify factors associated with fatigue outcomes in patients with ulcerative colitis (UC) or Crohn's disease (CD) initiating biologic treatment.

Methods: Data from adult Belgian patients with UC or CD enrolled in a prospective real-world study were utilized. Fatigue and QoL were assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F) and the Short Inflammatory Bowel Disease Questionnaire, respectively. Factors associated with fatigue outcomes were assessed using multivariate regression.

Results: 465 patients were included: 174 with UC and 291 with CD. Average FACIT-F scores indicated improvements in fatigue after 6 months, before stabilizing. A higher probability of fatigue disappearance was associated with clinical remission and was more likely in patients with UC than CD. Patients achieving clinical remission had lower probability of fatigue. Patients with fatigue improvements experienced greater QoL improvements than patients with fatigue persistence.

Conclusions: Real-world findings suggest fatigue partly improves in the first 6 months of biologic treatment. Clinical remission was associated with greater probability of fatigue disappearance and lower likelihood of fatigue persistence. Further research into factors associated with fatigue in patients with IBD is warranted.

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溃疡性结肠炎或克罗恩病患者开始生物治疗后的疲劳变化

背景：疲劳在炎症性肠病（IBDs）患者中很常见，并与生活质量（QoL）下降有关。目的：描述溃疡性结肠炎（UC）或克罗恩病（CD）患者开始生物治疗时的疲劳演变，并确定与疲劳结果相关的因素。方法：来自比利时成年UC或CD患者的数据被纳入一项前瞻性现实世界研究。疲劳和生活质量分别采用慢性疾病治疗-疲劳功能评估（FACIT-F）和短炎症性肠病问卷进行评估。使用多变量回归评估与疲劳结果相关的因素。结果：纳入465例患者：174例UC患者和291例CD患者。FACIT-F平均评分显示6个月后疲劳有所改善，随后趋于稳定。疲劳消失的可能性与临床缓解相关，UC患者比CD患者更有可能出现疲劳。达到临床缓解的患者疲劳的可能性更低。疲劳改善患者的生活质量比持续疲劳患者有更大的改善。结论：现实世界的研究结果表明，疲劳在生物治疗的前6个月部分改善。临床缓解与更大的疲劳消失可能性和更低的疲劳持续可能性相关。对IBD患者疲劳相关因素的进一步研究是有必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive and Liver Disease 医学-胃肠肝病学

CiteScore

6.10

自引率

2.20%

发文量

632

审稿时长

19 days

期刊介绍： Digestive and Liver Disease is an international journal of Gastroenterology and Hepatology. It is the official journal of Italian Association for the Study of the Liver (AISF); Italian Association for the Study of the Pancreas (AISP); Italian Association for Digestive Endoscopy (SIED); Italian Association for Hospital Gastroenterologists and Digestive Endoscopists (AIGO); Italian Society of Gastroenterology (SIGE); Italian Society of Pediatric Gastroenterology and Hepatology (SIGENP) and Italian Group for the Study of Inflammatory Bowel Disease (IG-IBD). Digestive and Liver Disease publishes papers on basic and clinical research in the field of gastroenterology and hepatology. Contributions consist of: Original Papers Correspondence to the Editor Editorials, Reviews and Special Articles Progress Reports Image of the Month Congress Proceedings Symposia and Mini-symposia.