Synthetic Strategies and Biological Activities of Teixobactin and its Analogs: A Review.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-01-07 DOI:10.2174/0115680266344835241125074030

Dalli Kumari, Govindappa Nagendra

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引用次数: 0

Abstract

Antibiotics are a revolutionary discovery in modern medicine, enabling the successful treatment of bacterial infections that were once untreatable and deadly. Teixobactin, a "head-toside- chain" cyclodepsipeptide, shows great promise as a lead compound for developing new antibiotics to deal with multi-drug-resistant bacterial infections. The unique pharmacological profile and intriguing structural characteristics of teixobactin, including its unusual amino acid residues (three D-amino acids and L-allo-enduracididine), have drawn the attention of multiple research groups seeking to create new antibiotics with innovative mechanisms. This review explores recent developments in the chemical structure of teixobactin, its biological role in cells, its biosynthetic production pathway, and how it disrupts bacteria (mode of action). Along with the structureactivity relationship (SAR) studies, this review also covers various synthetic approaches used to create teixobactin and its analogs. Finally, some observations regarding emerging patterns during the synthesis of unique analogs of teixobactin, as well as suggestions for further research and developments, are discussed.

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Teixobactin及其类似物的合成策略及生物活性研究进展

抗生素是现代医学的一项革命性发现，使曾经无法治愈和致命的细菌感染得以成功治疗。Teixobactin是一种“头向侧链”环沉积肽，作为开发新型抗生素以应对多重耐药细菌感染的先导化合物，具有很大的前景。teixobactin独特的药理学特征和有趣的结构特征，包括其不寻常的氨基酸残基（三个d -氨基酸和l - alloo -enduracididine），吸引了多个研究小组的注意，寻求创造具有创新机制的新抗生素。本文综述了teixobactin的化学结构、在细胞中的生物学作用、生物合成途径以及它如何破坏细菌（作用方式）等方面的最新进展。随着构效关系（SAR）的研究，本综述还涵盖了用于制造teixobactin及其类似物的各种合成方法。最后，对特克斯巴汀独特类似物合成过程中出现的模式进行了一些观察，并对进一步的研究和发展提出了建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.