{"title":"Pyrazoline and Pyrazoline Derivatives as Anti-Cancer Agents: Synthesis and Biological Activities: A Compressive Review.","authors":"Pushkar Kumar Ray, Ruchi Sharma, Abhishek Kumar","doi":"10.2174/0115680266339816241212081205","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>A heterocyclic molecule containing five rings, three carbon atoms, two nitrogen atoms, and a single endocyclic bond is called pyrazoline. Because of its intriguing electrical characteristics and potential for dynamic applications, pyrazoline is one type of electron-rich nitrogen carrier that is becoming more and more popular. This study synthesizes pyrazoline derivatives using a variety of techniques to demonstrate a highly biological function.</p><p><strong>Objective: </strong>Pharmaceutical chemistry has found the study of the biological activity of pyrazoline derivatives to be an interesting field. Pyrazolines find utility in numerous multipurpose applications. It has been discussed to examine the current study of patent literature on pyrazoline derivatives (2000-2024) that describes the introduction, general approach, synthesis scheme Structureactivity and relationship, marketed drug, and patents on anticancer activities.</p><p><strong>Conclusion: </strong>A recognized heterocyclic chemical is pyrazolines. Three carbon atoms and two adjacent nitrogen atoms make up the five-membered ring that is pyrazoline. A variety of methods are available to determine its synthesis. Extensive studies have been conducted in this field since it has been found that many pyrazoline derivatives have a crucial biological effect on anticancer activity. The application of pyrazoline as an anticancer agent is a fascinating moiety with a wealth of potential applications for further research by scientists.</p>","PeriodicalId":11076,"journal":{"name":"Current topics in medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current topics in medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0115680266339816241212081205","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: A heterocyclic molecule containing five rings, three carbon atoms, two nitrogen atoms, and a single endocyclic bond is called pyrazoline. Because of its intriguing electrical characteristics and potential for dynamic applications, pyrazoline is one type of electron-rich nitrogen carrier that is becoming more and more popular. This study synthesizes pyrazoline derivatives using a variety of techniques to demonstrate a highly biological function.
Objective: Pharmaceutical chemistry has found the study of the biological activity of pyrazoline derivatives to be an interesting field. Pyrazolines find utility in numerous multipurpose applications. It has been discussed to examine the current study of patent literature on pyrazoline derivatives (2000-2024) that describes the introduction, general approach, synthesis scheme Structureactivity and relationship, marketed drug, and patents on anticancer activities.
Conclusion: A recognized heterocyclic chemical is pyrazolines. Three carbon atoms and two adjacent nitrogen atoms make up the five-membered ring that is pyrazoline. A variety of methods are available to determine its synthesis. Extensive studies have been conducted in this field since it has been found that many pyrazoline derivatives have a crucial biological effect on anticancer activity. The application of pyrazoline as an anticancer agent is a fascinating moiety with a wealth of potential applications for further research by scientists.
期刊介绍：
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.
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