Cancer Integrin Imaging With 68 Ga-Trivehexin PET-CT in Head and Neck Squamous Cell Carcinoma Improves Diagnostic Accuracy.

IF 9.6 3区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Clinical Nuclear Medicine Pub Date : 2025-03-01 Epub Date: 2024-11-19 DOI:10.1097/RLU.0000000000005582
Ralph Emerson, Kanhaiyalal Agrawal, Parneet Singh, P Sai Sradha Patro, Navneet Kumar
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引用次数: 0

Abstract

Abstract: Oral squamous cell carcinoma (OSCC) is one of the most common malignancies worldwide. Locoregional nodal involvement by OSCC is commonly encountered. Current conventional and functional imaging modalities have limited diagnostic accuracy in nodal assessment, particularly in head and neck cancer. Thus, definitive management of head and neck malignancies customarily addresses the locoregional nodes along with the primary malignancy. However, OSCC, particularly tongue cancer, shows erratic lymphatic drainage and thus commonly requires extensive bilateral neck dissection, leading to significant morbidity. Cancer integrin imaging with 68 Ga-trivehexin PET-CT can offer highly specific result and thus has the potential for effective tailored management.

68Ga-Trivehexin PET-CT对头颈部鳞状细胞癌的肿瘤整合素成像提高了诊断准确性。
摘要口腔鳞状细胞癌(Oral squamous cell carcinoma, OSCC)是世界范围内最常见的恶性肿瘤之一。局部区域淋巴结受累的OSCC是常见的。目前的常规和功能成像方式在淋巴结评估中的诊断准确性有限,特别是在头颈癌中。因此,头颈部恶性肿瘤的最终治疗通常与原发恶性肿瘤一起处理局部淋巴结。然而,OSCC,特别是舌癌,淋巴引流不稳定,因此通常需要广泛的双侧颈部清扫,导致显著的发病率。68Ga-trivehexin PET-CT的癌症整合素成像可以提供高度特异性的结果,因此具有有效的定制管理的潜力。
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来源期刊
Clinical Nuclear Medicine
Clinical Nuclear Medicine 医学-核医学
CiteScore
2.90
自引率
31.10%
发文量
1113
审稿时长
2 months
期刊介绍: Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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