Recent Advances in Fluorescent Based Chemical Probes for the Detection of Perchlorate Ions.

Abstract

This review highlights recent advancements and challenges in fluorescence-based chemical sensors for selective and sensitive detection of perchlorate, a persistent environmental pollutant and global concern due to its health and safety implications. Perchlorate is a highly persistent inorganic pollutant found in drinking water, soil, and air, with known endocrine-disruptive properties due to its interference with iodide uptake by the thyroid gland. Human exposure mainly occurs through contaminated water and food. Additionally, perchlorates are prevalent in improvised explosives, causing numerous civilian casualties, making their detection important in a worldwide aspect. Fluorescence-based chemical sensors provide a valuable tool for the selective detection of perchlorate ions due to their simplicity and applicability across various fields, including biology, pharmacology, military, and environmental science. This review article overviews perchlorate chemistry, occurrence, and remediation strategies, compares regulatory limits, and examines fluorescence-based detection mechanisms. It systematically summarizes recent advancements in designing at least a dozen fluorescence-based chemical materials for detecting perchlorate in the environment over the past decade. Key focus areas include the design and molecular architecture of synthetic chemical chromophores for perchlorate sensing and the photochemistry mechanisms driving their effectiveness. The main findings indicate that there has been significant progress in the development of reliable and robust fluorescence-based sensors with higher selectivity and sensitivity for perchlorate detection. However, several challenges remain, such as improving detection limits and sensor stability. The review outlines potential future research directions, emphasizing the need for further innovation in sensor design and development. It aims to enhance understanding and spur advances that could create more efficient and robust chemical scaffolds for perchlorate sensing. By addressing current limitations and identifying opportunities for improvement, the review provides a comprehensive resource for researchers working to develop better detection methods for this significant environmental pollutant.