ABO Blood Group and Risk Associated With Sepsis-Associated Thrombocytopenia: A Single-Center Retrospective Study.

IF 7.7 1区医学 Q1 CRITICAL CARE MEDICINE

Critical Care Medicine Pub Date : 2025-02-01 Epub Date: 2024-11-15 DOI:10.1097/CCM.0000000000006523

Rong Liufu, Yan Chen, Jing-Yi Wang, Yang-Yan-Qiu Wang, Yao Wu, Wei Jiang, Chun-Yao Wang, Jin-Min Peng, Li Weng, Bin Du

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引用次数: 0

Abstract

Objectives: This study aimed to investigate the relationship between ABO blood group and sepsis-associated thrombocytopenia (SAT).

Design and setting: The primary outcome was SAT within the first 72 hours of ICU admission.

Patients: The retrospective study included 9113 patients diagnosed with sepsis from January 2014 to December 2022. A total of 6296 patients eventually were included into the study, who were divided into four groups based on ABO blood group.

Interventions: None.

Measurements and main results: A total of 2494 patients (39.6%) were diagnosed with SAT, and 712 (11.3%) of them experiencing severe SAT. The occurrence of SAT among the ABO blood groups was significantly lower in AB blood group compared with the other groups ( p = 0.032). Individuals in AB blood group were less likely to experience severe SAT ( p = 0.028). In multivariate analysis, B blood group (odds ratio [OR], 1.32; 95% CI, 1.05-1.67) and O (OR, 1.37; 95% CI, 1.09-1.72) were significantly associated with a higher occurrence of SAT compared with AB blood group. In multivariate analyses, A blood group (OR, 1.68; 95% CI, 1.16-2.42), B blood group (OR, 1.74; 95% CI, 1.74-2.50), and O blood group (OR, 1.72; 95% CI, 1.20-2.48) remained significantly risk factors associated with a higher occurrence of severe SAT compared with AB blood group.

Conclusions: B blood group and O were associated with an increased risk of SAT and severe SAT.

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ABO血型与脓毒症相关血小板减少症的相关风险：一项单中心回顾性研究

目的：探讨ABO血型与脓毒症相关性血小板减少症（SAT）的关系。设计和设置：主要终点是ICU入院前72小时内的SAT。患者：回顾性研究纳入了2014年1月至2022年12月诊断为败血症的9113例患者。最终共有6296名患者被纳入研究，他们根据ABO血型被分为四组。干预措施:没有。测量结果及主要结果：共2494例（39.6%）患者被诊断为SAT，其中重度SAT患者712例（11.3%）。ABO血型中AB血型的SAT发生率明显低于其他组（p = 0.032）。AB血型的个体发生严重SAT的可能性较低（p = 0.028）。多因素分析中，B血型(优势比[OR]， 1.32；95% CI, 1.05-1.67)和0 (OR, 1.37；95% CI, 1.09-1.72)与AB血型的SAT发生率显著相关。在多变量分析中，A血型(OR, 1.68；95% CI, 1.16-2.42)， B血型(OR, 1.74；95% CI, 1.74-2.50)， O型血(OR, 1.72；95% CI, 1.20-2.48)与AB血型相比，严重SAT的发生率较高，仍然是显著的危险因素。结论：B型血和O型血与SAT和严重SAT的风险增加相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Care Medicine 医学-危重病医学

CiteScore

16.30

自引率

5.70%

发文量

728

审稿时长

2 months

期刊介绍： Critical Care Medicine is the premier peer-reviewed, scientific publication in critical care medicine. Directed to those specialists who treat patients in the ICU and CCU, including chest physicians, surgeons, pediatricians, pharmacists/pharmacologists, anesthesiologists, critical care nurses, and other healthcare professionals, Critical Care Medicine covers all aspects of acute and emergency care for the critically ill or injured patient. Each issue presents critical care practitioners with clinical breakthroughs that lead to better patient care, the latest news on promising research, and advances in equipment and techniques.