Effect of diabetes and hyperglycaemia on the physical and mechanical properties of dentine: a systematic review.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2025-01-10 DOI:10.1007/s00784-025-06151-5

Kuan-Chieh Hwang, Joanne Jung Eun Choi, Haizal Mohd Hussaini, Paul R Cooper, Lara T Friedlander

{"title":"Effect of diabetes and hyperglycaemia on the physical and mechanical properties of dentine: a systematic review.","authors":"Kuan-Chieh Hwang, Joanne Jung Eun Choi, Haizal Mohd Hussaini, Paul R Cooper, Lara T Friedlander","doi":"10.1007/s00784-025-06151-5","DOIUrl":null,"url":null,"abstract":"Objectives: The aim of this systematic review was to assess the effect of DM (Type 1 and Type 2 Diabetes) and hyperglycaemia on the physical and mechanical properties of dentine which is critical for successful endodontic treatment.Method: An electronic search of the following databases: PubMed, MEDLINE, Web of Science and the grey literature was performed up until July 2024. In vitro and in vivo studies on the effect of DM or hyperglycaemia on the mechanical and physical properties of dentine were included. Non-English language literature was excluded.Results: Of the 234 articles identified, 15 met the inclusion criteria. Four studies evaluated how artificially induced glycation or natural glycation of dentine due to aging affects the mechanical properties of dentine. Five studies investigated the influence of Type 2 Diabetes (T2D) on dentine's mechanical properties, while two studies focused on the effects of Type 1 Diabetes (T1D). A further, four studies compared the effects of both T1D and T2D on the dentine. The studies were heterogeneous and a range of mechanical and physical properties were evaluated.Conclusion: DM and AGEs negatively influence the physical and mechanical properties of dentine however, there remains a paucity of evidence and further studies are needed.Clinical significance: Diabetes Mellitus (DM) is a chronic metabolic disease characterised by hyperglycaemia, an altered immune response and complications associated with collagen connective tissues. DM can influence bone metabolism and alter its physical and mechanical properties via glycation processes within collagen and changes to osteoblast activities. While bone and dentine share similarities, dentine is unique as it is intimately associated with the dental pulp. Inflammation within the pulp can induce calcification and tertiary dentine deposition and so exploring the influence of DM on the mechanical properties of dentine is warranted to understand the clinical significance.","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"55"},"PeriodicalIF":3.1000,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723890/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oral Investigations","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00784-025-06151-5","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: The aim of this systematic review was to assess the effect of DM (Type 1 and Type 2 Diabetes) and hyperglycaemia on the physical and mechanical properties of dentine which is critical for successful endodontic treatment.

Method: An electronic search of the following databases: PubMed, MEDLINE, Web of Science and the grey literature was performed up until July 2024. In vitro and in vivo studies on the effect of DM or hyperglycaemia on the mechanical and physical properties of dentine were included. Non-English language literature was excluded.

Results: Of the 234 articles identified, 15 met the inclusion criteria. Four studies evaluated how artificially induced glycation or natural glycation of dentine due to aging affects the mechanical properties of dentine. Five studies investigated the influence of Type 2 Diabetes (T2D) on dentine's mechanical properties, while two studies focused on the effects of Type 1 Diabetes (T1D). A further, four studies compared the effects of both T1D and T2D on the dentine. The studies were heterogeneous and a range of mechanical and physical properties were evaluated.

Conclusion: DM and AGEs negatively influence the physical and mechanical properties of dentine however, there remains a paucity of evidence and further studies are needed.

Clinical significance: Diabetes Mellitus (DM) is a chronic metabolic disease characterised by hyperglycaemia, an altered immune response and complications associated with collagen connective tissues. DM can influence bone metabolism and alter its physical and mechanical properties via glycation processes within collagen and changes to osteoblast activities. While bone and dentine share similarities, dentine is unique as it is intimately associated with the dental pulp. Inflammation within the pulp can induce calcification and tertiary dentine deposition and so exploring the influence of DM on the mechanical properties of dentine is warranted to understand the clinical significance.

查看原文本刊更多论文

糖尿病和高血糖对牙本质物理和机械特性的影响：系统综述。

目的：本系统综述的目的是评估糖尿病（1型和2型糖尿病）和高血糖对牙本质物理和机械特性的影响，这对成功的根管治疗至关重要。方法：对截止到2024年7月的PubMed、MEDLINE、Web of Science及灰色文献进行电子检索。在体外和体内研究了糖尿病或高血糖对牙本质力学和物理特性的影响。非英语文献被排除在外。结果：纳入的234篇文献中，15篇符合纳入标准。四项研究评估了人工诱导的牙本质糖基化或由于老化导致的牙本质自然糖基化对牙本质力学性能的影响。5项研究考察了2型糖尿病（T2D）对牙本质力学性能的影响，2项研究关注了1型糖尿病（T1D）对牙本质力学性能的影响。进一步，四项研究比较了T1D和T2D对牙本质的影响。这些研究是异质的，并且评估了一系列的机械和物理性质。结论：DM和AGEs对牙本质的物理力学性能有负面影响，但证据不足，有待进一步研究。临床意义：糖尿病（DM）是一种以高血糖、免疫反应改变和胶原结缔组织相关并发症为特征的慢性代谢性疾病。糖尿病可以通过胶原蛋白的糖基化过程和成骨细胞活性的变化影响骨代谢并改变其物理和机械特性。虽然骨和牙本质有相似之处，但牙本质是独特的，因为它与牙髓密切相关。牙髓内炎症可引起牙本质钙化和三级牙本质沉积，因此探讨DM对牙本质力学特性的影响对了解其临床意义是有必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.