A New Perspective on the Management of Primary Immunodeficiencies: Evaluation of Arrhythmia and Cardiac Diseases.

IF 1.9 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Pub Date : 2025-01-08 DOI:10.1159/000543381

Mustafa Ilker Inan, Yasemin Akgul Balaban, Ahmet Faruk Yagci, Ozgur Kartal, Baris Bugan, Fikriye Kalkan, Ezgi Sonmez, Fevzi Demirel, Ali Selcuk, Sait Yesillik

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引用次数: 0

Abstract

Introduction: Primary immunodeficiency diseases (PIDs) are a growing group of rarely seen diseases. Various clinical conditions like autoimmunity, lymphoproliferative/malignant diseases, chronic lung, and gastrointestinal system diseases have been identified which accompanies PIDs besides recurrent infections. However, there is a lack of information about accompanying cardiovascular diseases. We aimed to determine the frequency of cardiovascular diseases and arrhythmias in PID patients.

Methods: Forty-eight PID patients and 48 control group patients were included to this single-center, prospective controlled study. All patients underwent resting electrocardiogram, echocardiogram and 7-lead 24-h ambulatory electrocardiogram (Holter) monitoring assessed by an experienced cardiologist.

Results: Both supraventricular and ventricular extrasystoles were found to be statistically significantly higher in patient group in terms of frequency and sustained, non-sustained, and runs compared to control group. The median of total supraventricular extrasystoles was 8 (0-65) in patient group which was 0.5 (0-4.5) in control group (p < 0.001) while the median of total ventricular extrasystoles was 2 (0-45.5) and 0 (0-2) in two groups, respectively (p = 0.022). Eighteen patients (37.5%) had supraventricular and/or ventricular arrhythmias. The patient group had a statistically significantly higher systolic pulmonary artery pressure value compared to control group (20 [16-28] vs. 17.5 [15-25]; p = 0.036). We found 7 patients had 13 structural heart diseases including second degree or above valve pathologies in patient group whereas none of the control group patients had these diseases (p = 0.013).

Conclusion: With the positive findings of higher frequency and risk of arrhythmias and various structural heart diseases, we hope that our study will provide a new perspective on the management of PID patients, contributing positively to their survival and early prevention of cardiovascular comorbidities.

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原发性免疫缺陷治疗的新视角：心律失常和心脏疾病的评估。

原发性免疫缺陷疾病（PIDs）是一种越来越多的罕见疾病。各种临床条件，如自身免疫，淋巴增生性/恶性疾病，慢性肺部和胃肠道系统疾病已被确定，伴随着pid除了复发性感染。然而，缺乏相关的心血管疾病信息。我们的目的是确定PID患者心血管疾病和心律失常的频率。方法：选取48例PID患者和48例对照组患者进行单中心前瞻性对照研究。所有患者均接受静息心电图、超声心动图和由经验丰富的心脏病专家评估的7导联24小时动态心电图（Holter）监测。结果：与对照组相比，患者组室上期和室外期发生频率、持续、非持续、跑数均有统计学意义。患者组总室上性心动过速中位数为8(0-65)，对照组为0.5（0-4.5）。结论：心律失常及各种结构性心脏病的发生频率和风险较高，希望本研究能为PID患者的管理提供新的视角，对其生存及早期预防心血管合并症有积极作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology 医学-心血管系统

CiteScore

3.40

自引率

5.30%

发文量

审稿时长

1.5 months

期刊介绍： ''Cardiology'' features first reports on original clinical, preclinical and fundamental research as well as ''Novel Insights from Clinical Experience'' and topical comprehensive reviews in selected areas of cardiovascular disease. ''Editorial Comments'' provide a critical but positive evaluation of a recent article. Papers not only describe but offer critical appraisals of new developments in non-invasive and invasive diagnostic methods and in pharmacologic, nutritional and mechanical/surgical therapies. Readers are thus kept informed of current strategies in the prevention, recognition and treatment of heart disease. Special sections in a variety of subspecialty areas reinforce the journal''s value as a complete record of recent progress for all cardiologists, internists, cardiac surgeons, clinical physiologists, pharmacologists and professionals in other areas of medicine interested in current activity in cardiovascular diseases.