Epidemiology and clinical features of childhood malignant solid tumors in a single center in southwest China over 24 years.

IF 2 3区 医学 Q2 PEDIATRICS
Ting Li, Xiangpan Kong, Dawei He
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引用次数: 0

Abstract

Objective: This study aims to analyze the epidemiological characteristics and clinical features of childhood malignant solid tumors in a single center in southwest China, thereby providing a reliable basis for formulating prevention and control strategies and rational allocation of resources for these tumors.

Methods: Children less than 15 years old and under-diagnosed with malignant solid tumors for the first time at Children's Hospital of Chongqing Medical University (Children's Medical Center of Southwest China) from 2000 to 2023 were selected. They were classified according to the International Classification of Childhood Cancer, Third Edition (ICCC-3). A retrospective analysis was conducted on the disease spectrum composition and trends, distribution among different age groups and genders, and hospitalization characteristics of the patients.

Results: Over 24 years, there were a total of 4,777 cases of initial diagnosis of childhood malignant solid tumors, with a male-to-female ratio of 1.33:1. The median age was 4 years old, with 12.6% in the 0-year-old group, 41.6% in the 1 to 4-year-old group, 27.3% in the 5 to 9-year-old group, and 18.5% in the 10 to 14-year-old group. The top 3 malignant solid tumors by incidence rate were central nervous system (CNS) tumors (21.8%), neuroblastoma (17.8%), and lymphoma (13.9%). The ratio of pediatric malignant solid tumor patients to total hospital admissions rose from 0.14% in 2000 to 0.52% in 2021 but showed a declining trend after 2021. Childhood malignant solid tumors were primarily diagnosed due to the discovery of mass/occupancy (34.9%), abdominal pain/bloating (21.1%), or fever (6.3%). 74.4% of neuroblastomas and 54.7% of nephroblastomas were diagnosed at an advanced stage. 84.4% of patients underwent surgery, and 71.9% received chemotherapy, with chemotherapy rates showing an upward trend.

Conclusions: This study provides reliable information on the incidence characteristics and trends of childhood malignant solid tumors.

西南地区24年儿童恶性实体瘤流行病学及临床特征分析
目的:分析西南地区单一中心儿童恶性实体瘤的流行病学特征和临床特点,为制定防治策略和合理配置资源提供可靠依据。方法:选取2000 ~ 2023年重庆医科大学附属儿童医院(西南儿童医学中心)首次确诊恶性实体瘤年龄小于15岁的患儿。他们根据国际儿童癌症分类,第三版(ICCC-3)进行分类。回顾性分析患者的疾病谱组成及趋势、不同年龄组和性别的分布、住院特点。结果:24年间,首次诊断儿童恶性实体瘤共4777例,男女比例为1.33:1。年龄中位数为4岁,其中0岁组占12.6%,1 ~ 4岁组占41.6%,5 ~ 9岁组占27.3%,10 ~ 14岁组占18.5%。恶性实体瘤发病率前3位依次为中枢神经系统瘤(21.8%)、神经母细胞瘤(17.8%)、淋巴瘤(13.9%)。儿童恶性实体瘤患者占住院总人数的比例从2000年的0.14%上升到2021年的0.52%,但2021年后呈下降趋势。儿童恶性实体瘤主要诊断为发现肿块/占位(34.9%)、腹痛/腹胀(21.1%)或发热(6.3%)。74.4%的神经母细胞瘤和54.7%的肾母细胞瘤被诊断为晚期。84.4%的患者接受了手术,71.9%的患者接受了化疗,化疗率呈上升趋势。结论:本研究为儿童恶性实体瘤的发病率特点和趋势提供了可靠的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Pediatrics
BMC Pediatrics PEDIATRICS-
CiteScore
3.70
自引率
4.20%
发文量
683
审稿时长
3-8 weeks
期刊介绍: BMC Pediatrics is an open access journal publishing peer-reviewed research articles in all aspects of health care in neonates, children and adolescents, as well as related molecular genetics, pathophysiology, and epidemiology.
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