Systemic lupus erythematosus and male reproductive health: A systematic review and meta-analysis

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2025-01-07 DOI:10.1016/j.autrev.2025.103742

Jie Zhu , Qingmiao Zhu , Xiaolong Li , Tianshu Shen , Xiaowei Shi , Ting Zhao

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引用次数: 0

Abstract

Objective

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect various organs. Male SLE patients often face reproductive health challenges, but research on male sexual and reproductive health in SLE remains limited. This systematic review and meta-analysis aimed to explore the effects of SLE and its related factors on male sexual function and reproductive health.

Methods

The PubMed, Cochrane library, Embase, Web of Science, Wanfang Data, and China National Knowledge Infrastructure (CNKI) databases were examined from January 2000 to December 2024. Data extraction and quality assessment were performed by two reviewers. Meta-analysis was carried out using Review Manager 5.3 software, and the risk of bias was assessed using the AHRQ checklist. The following outcomes were evaluated: sexual function, reproductive hormones and fertility.

Results

In the literature search, 5002 articles were identified, of which 9 studies met the inclusion criteria. Meta-analysis showed a significantly higher incidence of erectile dysfunction (ED) in SLE patients (OR = 7.44; 95 % CI = 5.00 to 11.06, p < 0.001). SLE patients also had higher levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) compared to controls (FSH: MD = 4.02; 95 % CI = 1.47 to 6.57; p = 0.002; LH: MD = 2.21; 95 % CI = 1.10 to 3.32; p < 0.001). Semen analysis showed a significant decrease in sperm count in SLE patients (MD = -0.54; 95 % CI = -0.86 to −0.22; p < 0.001).

Conclusions

Male SLE patients are more likely to have problems with sexual function, reproductive hormones and sperm quality. These findings emphasize the need for increased clinical awareness and interventions focused on male sexual and reproductive health in SLE patients.

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系统性红斑狼疮与男性生殖健康：系统综述和荟萃分析。

目的：系统性红斑狼疮（SLE）是一种可累及多脏器的慢性自身免疫性疾病。男性SLE患者经常面临生殖健康方面的挑战，但对SLE患者男性性健康和生殖健康的研究仍然有限。本系统综述和荟萃分析旨在探讨SLE及其相关因素对男性性功能和生殖健康的影响。方法：检索2000年1月至2024年12月的PubMed、Cochrane library、Embase、Web of Science、万方数据和中国知网数据库。数据提取和质量评估由两名审稿人完成。meta分析采用Review Manager 5.3软件进行，偏倚风险采用AHRQ检查表进行评估。评估以下结果：性功能、生殖激素和生育能力。结果：在文献检索中，共检索到5002篇文献，其中9篇符合纳入标准。荟萃分析显示，SLE患者勃起功能障碍（ED）的发生率显著更高(OR = 7.44；95 % CI = 5.00 ~ 11.06，p 结论：男性SLE患者更容易出现性功能、生殖激素和精子质量方面的问题。这些发现强调需要提高对SLE患者男性性健康和生殖健康的临床意识和干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.