Association between sarcopenic obesity and risk of frailty in older adults: a systematic review and meta-analysis.

IF 6 2区医学 Q1 GERIATRICS & GERONTOLOGY

Age and ageing Pub Date : 2025-01-06 DOI:10.1093/ageing/afae286

Yao Gengxin, Ma Xuehan, Wan Xinyu, Yang Yali, Xu Yiran, Zheng Lishuang, Qiu Yiming, Li Guichen, Chen Li

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引用次数: 0

Abstract

Background: Age-related changes in body composition such as muscle loss can lead to sarcopenia, which is closely associated with frailty. However, the effect of body fat accumulation on frailty in old age remains unclear. In particular, the association between the combination of these two conditions, known as sarcopenic obesity, and frailty in older adults is unclear.

Objective: To synthesise the association between sarcopenic obesity and the risk of frailty and to investigate the role of obesity in the risk of frailty in old age.

Methods: Six databases were searched from inception to 29 September 2024. Two reviewers independently extracted the data and assessed the risk of bias for the included observational studies using the adapted Newcastle-Ottawa scale. The control groups consisted of robust, obese and sarcopenic individuals. Meta-analyses were performed to examine the risk of frailty due to sarcopenic obesity and the role of obesity in frailty amongst sarcopenic older adults.

Results: Sixteen eligible studies were included in meta-analyses from 1098 records. Compared to robust individuals, older adults with sarcopenic obesity were more vulnerable to frailty [odds ratio (OR), 3.76; 95% confidence interval (CI), 2.62 to 5.39; I2 = 79.3%; P < .0001]. Obesity was not associated with the risk of frailty (OR, 1.23; 95% CI, 0.99 to 1.53; I2 = 0.0%; P = .501) in sarcopenic older adults.

Conclusions: Sarcopenic obesity is associated with a high risk of frailty. Sarcopenia and obesity may have synergistic effects on frailty in older adults.

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老年人肌肉减少型肥胖与虚弱风险之间的关系：系统回顾和荟萃分析。

背景：与年龄相关的身体成分变化，如肌肉损失，可导致肌肉减少症，这与虚弱密切相关。然而，体内脂肪堆积对老年虚弱的影响尚不清楚。特别是，这两种情况的结合，即肌肉减少性肥胖，与老年人虚弱之间的关系尚不清楚。目的：综合肌肉减少型肥胖与衰弱风险的关系，探讨肥胖在老年衰弱风险中的作用。方法：检索自建库至2024年9月29日的6个数据库。两名审稿人独立提取数据，并使用纽卡斯尔-渥太华量表评估纳入的观察性研究的偏倚风险。对照组由健壮、肥胖和肌肉减少的个体组成。进行荟萃分析，以检查肌肉减少型肥胖引起的虚弱风险，以及肥胖在肌肉减少型老年人中虚弱的作用。结果：从1098份记录中纳入了16项符合条件的研究。与健壮的个体相比，患有肌肉减少性肥胖的老年人更容易出现虚弱[优势比（OR）， 3.76；95%置信区间（CI）， 2.62 ~ 5.39；i2 = 79.3%；结论：肌肉减少型肥胖与脆弱的高风险相关。骨骼肌减少症和肥胖可能对老年人的虚弱有协同作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Age and ageing 医学-老年医学

CiteScore

9.20

自引率

6.00%

发文量

796

审稿时长

4-8 weeks

期刊介绍： Age and Ageing is an international journal publishing refereed original articles and commissioned reviews on geriatric medicine and gerontology. Its range includes research on ageing and clinical, epidemiological, and psychological aspects of later life.