Assessment of transpulmonary thermodilution, ultrasound dilution, and esophageal Doppler against direct pulmonary artery flow for cardiac output monitoring in anesthetized cats.
Pen-Ting Liao, Michael Tillson, Stuart Clark-Price, Kendon Kuo, Katherine Gerken, Aina Claret
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引用次数: 0
Abstract
Objective: To assess the agreement of transpulmonary thermodilution (TPTD) and transpulmonary ultrasound dilution (TPUD) against direct measurement of main pulmonary artery flow with an ultrasound transit time flow probe (UTF) over a wide range of conditions in anesthetized cats. Additionally, the trending ability of TPTD, TPUD, and esophageal Doppler ultrasonography (EDU) was evaluated against UTF.
Methods: 12 purpose-bred cats were used. One cat was used for a pilot study. The cats were instrumented according to the manufacturer's recommendation. Paired measurements were made over a wide range of cardiac output. Agreement was analyzed with Bland-Altman analysis with repeated measures, and trending ability was assessed by 4-quadrant plot and concordance rate. Interchangeable was defined as percentage error less than simplified total error. Acceptable trending was defined as concordance rate > 95%.
Results: Bias and percentage error were -0.084 L·min-1 and 38.2% for TPTD and -0.041 L·min-1 and 52.9% for TPUD. The concordance rate was 100%, 95.5%, and 64% to 65% for TPTD, TPUD, and EDU, respectively.
Conclusions: Both TPTD and TPUD were not interchangeable to UTF. Both TPTD and TPUD provided acceptable trending ability but not EDU.
Clinical relevance: Transpulmonary thermodilution and TPUD allow detection of the direction of cardiac output changes in anesthetized cats but not EDU. Clinical and research use of these 3 devices warrants careful consideration of the limitations presented in this study.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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