Prospective evaluation of opioid cessation in patients with suspected Opioid-induced esophageal dysfunction (OIED).

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2025-01-10 DOI:10.14309/ajg.0000000000003297

A Ezquerra-Durán, L Alcalá-González, I K Araujo, J Alcedo, J Serra, E Barba

引用次数: 0

Abstract

Introduction: The causal relationship between chronic opioid use and esophageal motor dysfunction in symptomatic patients has not been established.

Methods: A prospective before-and-after multicenter study, including chronic active opioid patients referred for esophageal motility tests due to non-obstructive dysphagia.

Results: 37 patients were evaluated, 27 (73%) had criteria of opioid-induced esophageal dysfunction (OIED). In 19 patients who discontinued opioids for at least 7 days, esophageal motor disorders resolved in 10 (52.6%), accompanied by a clinical success response (defined as Eckardt ≤3) in 64.3%.

Discussion: Discontinuation of opioids is associated with clinical and esophageal motility improvement in up to half of the patients.

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阿片类药物戒断对疑似阿片类药物引起的食管功能障碍（OIED）患者的前瞻性评价。

慢性阿片类药物使用与有症状患者食管运动功能障碍之间的因果关系尚未确定。方法：一项前瞻性多中心研究，包括慢性活动性阿片类药物患者因非阻塞性吞咽困难而转介食管运动检查。结果：37例患者被评估，27例（73%）符合阿片类药物诱导的食管功能障碍（OIED）标准。在19例停用阿片类药物至少7天的患者中，10例（52.6%）食管运动障碍得到缓解，64.3%的患者伴有临床成功反应（定义为Eckardt≤3）。讨论：停药阿片类药物与多达一半患者的临床和食管运动改善有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.