Laccase Mediated One-Pot, Green Synthesis of Thiazoles, β-Keto Sulfones and Imidazopyridines.

Abstract

We report the first in situ reaction of the β-haloketones obtained from laccase catalysed oxidation of secondary alcohol 2-halo phenylethanol's in present study. To the best of our knowledge, this is the first ever fusion of laccase catalysed oxidation reaction with green organic synthetic reaction. The methodology employs molecular oxygen to oxidize secondary alcohol in biphasic medium by laccase from T. giganteum AGHP, to obtain β-haloketones. This research provides environmentally benign access to thiazole, β-ketosulfone and imidazopyridine derivatives in good to very good yields with wide functional group tolerance.