Prenatal exposure to particulates and anthropometry through 9 years of age in a birth cohort

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-01-09 DOI:10.1111/ijpo.13202

Ian R. Trees, Abhisek Saha, Diane L. Putnick, Priscilla K. Clayton, Pauline Mendola, Rajeshwari Sundaram, Edwina H. Yeung

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引用次数: 0

Abstract

Background

Previous research observed links between prenatal air pollution and risk of childhood obesity but the timing of the exposure is understudied. Aim: We examined prenatal particulate matter (PM₁₀, PM_2.5) exposure and child anthropometry.

Materials & Methods

Children's body mass index z-scores (zBMI) at 0–3 (N = 4370) and 7–9 (n = 1191) years were derived from reported anthropometry at paediatric visits. We ran linear mixed models for six windows, adjusting for maternal, child, and neighbourhood factors.

Results

PM₁₀ exposure across pregnancy and at multiple windows was associated with higher zBMI in both early and middle childhood. For instance, one interquartile range increase in PM₁₀ exposure during the first 2 weeks of pregnancy was associated with higher zBMI at 0–3 (0.05, 95% CI: 0.01, 0.10) and 7–9 (0.14, 95% CI: 0.02, 0.23). PM_2.5 exposure during the final 2 weeks of gestation was associated with higher zBMI at 7–9 years (B: 0.12, 95% CI: 0.04, 0.22).

Conclusion

Even at low levels of air pollution, prenatal PM₁₀ exposure was associated with higher zBMI in childhood.

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出生队列中9岁前的产前颗粒物暴露和人体测量。

背景：先前的研究发现了产前空气污染与儿童肥胖风险之间的联系，但暴露的时间尚未得到充分研究。目的：我们检查了产前颗粒物（PM10, PM2.5）暴露和儿童人体测量。材料与方法：0-3岁（N = 4370）和7-9岁（N = 1191）儿童身体质量指数z-分数（zBMI）来源于儿科就诊时报告的人体测量数据。我们运行了六个窗口的线性混合模型，调整了母亲、儿童和邻里因素。结果：PM10在怀孕期间和多个窗口暴露与儿童早期和中期较高的zBMI有关。例如，怀孕前两周PM10暴露增加一个四分位数范围与0-3 （0.05,95% CI: 0.01, 0.10）和7-9 （0.14,95% CI: 0.02, 0.23）较高的zBMI相关。妊娠最后2周暴露于PM2.5与7-9岁时较高的zBMI相关（B: 0.12, 95% CI: 0.04, 0.22）。结论：即使在低水平的空气污染下，产前PM10暴露与儿童时期较高的zBMI有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.