Ultrasound-Triggered Oxygen Release System for Accelerating Wound Healing of Diabetic Foot Ulcers

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Deli Zhuge, Siting Yang, Xiehua Pan, Yingnan Xiao, Xinji Wang, Wenqian Wang, Wenli Gao, Ailing Lu, Binbin Shi, Bin Chen, Yingzheng Zhao
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Abstract

Diabetic foot ulcer (DFU) is a common complication of chronic diabetes mellitus. Oxygen plays a critical role in the healing process of DFU wounds by promoting cell migration and neovascularization. However, clinical hyperbaric oxygen (HBO) therapy predominantly uses systemic oxygen administration, posing challenges in inadequate DFU local oxygen penetration and potential ectopic organs oxygen toxicity. To address these challenges, a strategy to encapsulate oxygen with lipid microbubbles (OMBs) and incorporate them into a body temperature-sensitive heparin-pluronic copolymer hydrogel (HP/OMBs) have been developed. HP/OMBs showed high biocompatibility both in vitro and in vivo. After in situ administration, oxygen can be released from HP/OMBs to the local deep site of the DFU wounds under ultrasound (US) triggering. Thus, given its biocompatibility and practicality, the combined action of HP/OMBs and the US has important translational value in accelerating diabetic chronic wound healing.

Abstract Image

超声触发氧释放系统加速糖尿病足溃疡伤口愈合。
糖尿病足溃疡(DFU)是慢性糖尿病的常见并发症。氧通过促进细胞迁移和新生血管在DFU伤口愈合过程中起关键作用。然而,临床高压氧(HBO)治疗主要采用全身给氧,这给DFU局部氧渗透不足和潜在的异位器官氧毒性带来了挑战。为了应对这些挑战,研究人员开发了一种将氧与脂质微泡(OMBs)包封并将其纳入体温敏感型肝素-pluronic共聚物水凝胶(HP/OMBs)的策略。HP/OMBs在体外和体内均表现出较高的生物相容性。原位给药后,在超声(US)触发下,氧气可以从HP/OMBs释放到DFU伤口的局部深部。因此,鉴于其生物相容性和实用性,HP/OMBs与US的联合作用在加速糖尿病慢性伤口愈合方面具有重要的转化价值。
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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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