Ternary Metal (W–Ni–Sr) Oxide@Polypyrrole Nanotubes: A New Frontier in the Electrochemical Detection of Promethazine Hydrochloride (PMHC)

IF 3.7 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Langmuir Pub Date : 2025-01-08 DOI:10.1021/acs.langmuir.4c03820

Shilpa Purushothama, Sirisha Subbareddy, Santhosh Arehalli Shivamurthy, Sandeep Shadakshari, Shruthi Chinnakurli Dwarakanath, Venkata Narayana Palakollu

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引用次数: 0

Abstract

Promethazine hydrochloride (PMHC) is a vital drug that is used as an anticholinergic, antipsychotic, antihistaminic, analgesic, sedative, and neuroleptic. However, the overdosage of PMHC also causes reproductive variations, cardiac changes, hypotension, and endocrinal variations. Hence, the detection of PMHC is crucial. Therefore, in this work an electrochemical method for the detection of PMHC is reported. The fabrication for the modified electrode is built with tungsten (W), nickel (N), and strontium (S) ternary oxide (tWNSO). To the best of our knowledge, this tWNSO ternary oxide preparation is reported for the first time in the literature. The prepared ternary oxide is deposited on the polypyrrole nanotubes, and this nanocomposite that is formed is confirmed by various physical characterizations like XRD, SEM, TEM, UV–vis spectroscopy, FTIR spectroscopy, and also DFT studies for PMHC. Thus, the nanocomposite obtained is used as a working electrode for the detection of PMHC. The fabricated tWNSO/PPyNTs/GCE has an effective surface area of 0.0436 cm². Also, no fouling was observed. The limit of detection of the analyte PMHC is 3.66 nM, the limit of quantification is 11.10 nM, and the sensitivity of the fabricated electrode in identifying the analyte is found to be 20.10 μA μM^–1 cm^–2. Thus, the modified working electrode effectively detects the analyte PMHC while demonstrating excellent stability and reproducibility.

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来源期刊

Langmuir 化学-材料科学：综合

CiteScore

6.50

自引率

10.30%

发文量

1464

审稿时长

2.1 months

期刊介绍： Langmuir is an interdisciplinary journal publishing articles in the following subject categories: Colloids: surfactants and self-assembly, dispersions, emulsions, foams Interfaces: adsorption, reactions, films, forces Biological Interfaces: biocolloids, biomolecular and biomimetic materials Materials: nano- and mesostructured materials, polymers, gels, liquid crystals Electrochemistry: interfacial charge transfer, charge transport, electrocatalysis, electrokinetic phenomena, bioelectrochemistry Devices and Applications: sensors, fluidics, patterning, catalysis, photonic crystals However, when high-impact, original work is submitted that does not fit within the above categories, decisions to accept or decline such papers will be based on one criteria: What Would Irving Do? Langmuir ranks #2 in citations out of 136 journals in the category of Physical Chemistry with 113,157 total citations. The journal received an Impact Factor of 4.384*. This journal is also indexed in the categories of Materials Science (ranked #1) and Multidisciplinary Chemistry (ranked #5).