Thermoelectrochemical Method for Quantification of the Micellization Entropy of Redox-Active Polymers

IF 5.1 Q1 POLYMER SCIENCE

ACS Macro Letters Pub Date : 2025-01-09 DOI:10.1021/acsmacrolett.4c00773

Mizuha Ujita, Hongyao Zhou, Teppei Yamada

{"title":"Thermoelectrochemical Method for Quantification of the Micellization Entropy of Redox-Active Polymers","authors":"Mizuha Ujita, Hongyao Zhou, Teppei Yamada","doi":"10.1021/acsmacrolett.4c00773","DOIUrl":null,"url":null,"abstract":"Redox-active micelles undergo reversible association and dissociation in response to their redox potential and are promising materials for various applications, such as drug delivery and bioimaging. Evaluation of the micellization entropy is critical in controlling the thermodynamics of micelle formation. However, conventional methods such as isothermal titration calorimetry and surface tensiometry require a long measurement time to observe changes in the heat flow or the surface tension caused by the micellization. Here we report a thermoelectrochemical method to quantify the entropy change produced by redox-active micelles. A set of poly(ethyl glycidyl ether-<i>b</i>-ethylene oxide)phenothiazine (PT-EGE-EO) with varied chain length were synthesized, and their micellization entropy was calculated from the temperature-dependent changes of the equilibrium potential. This thermoelectrochemical method enables a quick evaluation of the micellization entropy with only a single sample preparation and temperature sweep. The obtained results showed a reasonable agreement with the conventional surface tensiometry and isothermal titration calorimetry, indicating that the thermoelectrochemical method is a promising alternative for quantification of the micellization entropy.","PeriodicalId":18,"journal":{"name":"ACS Macro Letters","volume":"1 1","pages":""},"PeriodicalIF":5.1000,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Macro Letters","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acsmacrolett.4c00773","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}

引用次数: 0

Abstract

Redox-active micelles undergo reversible association and dissociation in response to their redox potential and are promising materials for various applications, such as drug delivery and bioimaging. Evaluation of the micellization entropy is critical in controlling the thermodynamics of micelle formation. However, conventional methods such as isothermal titration calorimetry and surface tensiometry require a long measurement time to observe changes in the heat flow or the surface tension caused by the micellization. Here we report a thermoelectrochemical method to quantify the entropy change produced by redox-active micelles. A set of poly(ethyl glycidyl ether-b-ethylene oxide)phenothiazine (PT-EGE-EO) with varied chain length were synthesized, and their micellization entropy was calculated from the temperature-dependent changes of the equilibrium potential. This thermoelectrochemical method enables a quick evaluation of the micellization entropy with only a single sample preparation and temperature sweep. The obtained results showed a reasonable agreement with the conventional surface tensiometry and isothermal titration calorimetry, indicating that the thermoelectrochemical method is a promising alternative for quantification of the micellization entropy.

Abstract Image

查看原文本刊更多论文

定量氧化还原活性聚合物胶束熵的热电化学方法

氧化还原活性胶束根据其氧化还原电位进行可逆的结合和解离，是各种应用的有前途的材料，如药物输送和生物成像。胶束熵的评估对于控制胶束形成的热力学是至关重要的。然而，传统的等温滴定量热法和表面张力法等方法需要较长的测量时间才能观察到热流或胶束化引起的表面张力的变化。在这里，我们报告了一种热电化学方法来量化氧化还原活性胶束产生的熵变。合成了一组不同链长的聚（乙基缩水甘油酯醚-b-环氧乙烷）吩噻嗪（PT-EGE-EO），并根据平衡势的温度变化计算了它们的胶束熵。这种热电化学方法可以快速评估胶束熵，只需要一次样品制备和温度扫描。所得结果与传统的表面张力法和等温滴定量热法有较好的一致性，表明热电化学方法是一种很有前途的胶束熵定量方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Macro Letters 化学-

CiteScore

10.40

自引率

3.40%

发文量

209

审稿时长

1 months

期刊介绍： ACS Macro Letters publishes research in all areas of contemporary soft matter science in which macromolecules play a key role, including nanotechnology, self-assembly, supramolecular chemistry, biomaterials, energy generation and storage, and renewable/sustainable materials. Submissions to ACS Macro Letters should justify clearly the rapid disclosure of the key elements of the study. The scope of the journal includes high-impact research of broad interest in all areas of polymer science and engineering, including cross-disciplinary research that interfaces with polymer science. With the launch of ACS Macro Letters, all Communications that were formerly published in Macromolecules and Biomacromolecules will be published as Letters in ACS Macro Letters.