Developing a Novel Agrochemical-Based MOF: A Multifunctional Platform with Herbicidal and Antibacterial Activities

IF 8.3 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
MCarmen Contreras, Pablo Salcedo-Abraira, Andoni Zabala-Lekuona, Antonio Rodríguez-Diéguez, Sara Rojas
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Abstract

Excessive and uncontrolled application of agrochemicals has resulted in contamination of terrestrial and aquatic environments. In the past decade, metal–organic frameworks (MOFs) have been studied as agrochemical release systems to enhance efficiency while reducing the leaching of toxic molecules to the environment. In this work, we take a further step and use organic agrochemicals as linkers in the preparation of MOFs, which we have called AgroMOFs. Particularly, we have prepared a novel 2D framework, named GR-MOF-20, based on the flexible herbicide glyphosine (H5Gly) and the widely used antibacterial and fungicide Cu2+. After complete characterization by single-crystal and powder X-ray diffraction and high-performance liquid chromatography (HPLC), a fascinating transformation of the structure to a novel 3D-MOF (GR-MOF-21) after in water is observed, together with a burst degradation (86.0 ± 3.2% after 72 h). Considering the bioactivity of its building blocks (H5Gly and Cu2+), the combined herbicidal and antibacterial activities of GR-MOF-21 were demonstrated. Aqueous solutions prepared with GR-MOF-20 (450 mg L–1) demonstrated a better inhibition effect (21.7 ± 2.9% after 7 days) in the germination of seeds of the invasive weed Lolium multiflorum than the free H5Gly (13.3 ± 2.9%). Further, the selectivity of GR-MOF-21 was tested against a nontarget plant (wheat, Triticum aestivum). Finally, GR-MOF-21 showed an important antibacterial activity against Escherichia coli and Pseudomonas syringae, achieving the results obtained with Cu2+ solutions. These observations demonstrated that the use of herbicide and antibacterial units in the MOF construction is an efficient approach to controlling bacteria and weed plants without damaging wheat crops.

Abstract Image

基于农用化学品的新型MOF:具有除草和抗菌活性的多功能平台
过度和不受控制地使用农用化学品已造成陆地和水生环境的污染。在过去的十年中,金属有机框架(MOFs)作为农用化学品释放系统被研究以提高效率,同时减少有毒分子的浸出到环境中。在这项工作中,我们进一步使用有机农用化学品作为连接剂来制备mof,我们称之为agromof。特别是,我们基于柔性除草剂草甘膦(H5Gly)和广泛使用的抗菌和杀菌剂Cu2+制备了一种新的二维框架,命名为GR-MOF-20。通过单晶和粉末x射线衍射以及高效液相色谱(HPLC)对其进行了完整的表征,观察到GR-MOF-21在水中发生了令人惊叹的结构转变,并在72 h后发生了突然降解(86.0±3.2%)。考虑到其构建块(H5Gly和Cu2+)的生物活性,GR-MOF-21具有除草和抗菌的联合活性。GR-MOF-20 (450 mg L-1)水溶液对入侵杂草多花黑麦草种子萌发的抑制作用(7 d后为21.7±2.9%)优于游离的H5Gly(13.3±2.9%)。此外,研究了GR-MOF-21对非目标植物小麦(Triticum aestivum)的选择性。最后,GR-MOF-21对大肠杆菌和丁香假单胞菌表现出重要的抗菌活性,达到Cu2+溶液的抑菌效果。这些结果表明,在MOF建设中使用除草剂和抗菌单元是一种有效的控制细菌和杂草植物而不损害小麦作物的方法。
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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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