Polyglyoxylamide hydrogels for the traceless stimulus-mediated release of covalently-immobilized drugs†

IF 4.1 2区 化学 Q2 POLYMER SCIENCE
Jue Gong, Burak Tavsanli and Elizabeth R. Gillies
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引用次数: 0

Abstract

Hydrogels can be used in a wide range of applications from personal care products to drug delivery vehicles. Particularly for drug delivery, it is desirable to control the release of the loaded cargo as well as the hydrogel degradation time. Self-immolative hydrogels have been recently investigated to enable the stimulus-mediated breakdown of the hydrogel, which can also modulate to some extent the release of loaded drugs. However, when the drug was loaded into the hydrogel using non-covalent interactions, the background release rate of the drug in the absence of the stimulus was relatively rapid. Thus, we report here a new hydrogel system based on an acetal end-capped self-immolative polyglyoxylamide backbone with photo-responsive linkers as pendent groups to enable the covalent conjugation of amine-functionalized drugs. Using phenylalanine methyl ester as a model drug, we showed that hydrogels were successfully prepared with 96% equilibrium water content and a compressive modulus of 5.5 kPa. Light irradiation stimulated the rapid and traceless release of the model drug, while no detectable release was observed without irradiation. Furthermore, the PGAm backbone depolymerized selectively at mildly acidic pH. This system therefore provides a new hydrogel platform enabling a high level of control over both hydrogel breakdown and drug release.

Abstract Image

聚乙醛酰胺水凝胶用于无痕迹刺激介导的共价固定药物释放
水凝胶可用于广泛的应用,从个人护理产品到药物输送载体。特别是对于药物递送,需要控制装载货物的释放以及水凝胶降解时间。自焚水凝胶最近被研究,以使刺激介导的水凝胶分解,这也可以在一定程度上调节负载药物的释放。然而,当药物通过非共价相互作用加载到水凝胶中时,在没有刺激的情况下,药物的本底释放速度相对较快。因此,我们在这里报道了一种新的水凝胶体系,该体系基于缩醛端盖自焚型聚乙醛酰胺骨架,光响应连接体作为悬垂基团,使胺官能化药物的共价偶联成为可能。以苯丙氨酸甲酯为模型药物,成功制备了平衡含水量为96%、压缩模量为5.5 kPa的水凝胶。光照射刺激模型药物快速无迹释放,而无光照射则未观察到可检测到的释放。此外,PGAm主链在轻度酸性ph下选择性解聚。因此,该系统提供了一种新的水凝胶平台,可以高度控制水凝胶的分解和药物释放。
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来源期刊
Polymer Chemistry
Polymer Chemistry POLYMER SCIENCE-
CiteScore
8.60
自引率
8.70%
发文量
535
审稿时长
1.7 months
期刊介绍: Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.
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