Advancing de novo lipogenesis: Genetic and metabolic insights

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-01-07 DOI:10.1016/j.cmet.2024.12.001

Sean M. Hartig, Mark A. Herman

引用次数: 0

Abstract

De novo lipogenesis (DNL) is the process whereby cells synthesize fatty acids from acetyl-CoA, contributing to steatosis in fatty liver disease. Two new studies, using genetic mouse models, metabolomics, and pharmacology, identified alternative pathways in DNL and unexpected physiological effects when targeting key enzymes in this pathway.

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推进新生脂肪生成：遗传和代谢的见解

从头脂肪生成（DNL）是细胞从乙酰辅酶a合成脂肪酸的过程，有助于脂肪肝疾病中的脂肪变性。两项利用小鼠遗传模型、代谢组学和药理学的新研究发现了DNL的替代途径，以及针对该途径中的关键酶时意想不到的生理效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.