Exposure to residential air pollution and the development of functional connectivity of brain networks throughout adolescence

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-02-01 DOI:10.1016/j.envint.2024.109245

Michelle S.W. Kusters , Laura Granés , Sami Petricola , Henning Tiemeier , Ryan L. Muetzel , Mònica Guxens

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引用次数: 0

Abstract

Background

A few studies linked air pollution to differences in functional connectivity of resting-state brain networks in children, but how air pollution exposure affects the development of brain networks remains poorly understood. Therefore, we studied the association of air pollution exposure from birth to 3 years and one year before the first imaging assessment with the development of functional connectivity across adolescence.

Methods

We utilized data from 3,626 children of the Generation R Study (The Netherlands). We estimated residential exposure to PM₁₀, PM_2.5, PM_2.5 absorbance, NO_X, and NO₂ with land-use regression models. Between- and within-network functional connectivity was calculated for 13 cortical networks, and the amygdala, hippocampus, and caudate nucleus at two assessments (8.6–12.0 and 12.6–17.1 years), resulting in 4,628 scans (2,511 for assessment 1 and 2,117 for assessment 2) from 3,626 individuals. We investigated the association between air pollution and functional connectivity with linear mixed models adjusted for life-style and socioeconomic variables, and corrected for multiple testing.

Results

Higher exposure to PM_2.5 from birth to 3 years was associated with persistently lower functional connectivity over time between the amygdala and the ventral attention, somatomotor hand, and auditory networks throughout adolescence (e.g. −0.027 functional connectivity [95 % CI −0.040; −0.013] amygdala – ventral attention network per 5 μg/m³ higher PM_2.5). Higher exposure to PM₁₀ one year before the first imaging assessment was associated with persistently lower functional connectivity between the salience and medial-parietal networks throughout adolescence. Air pollution was not associated with a faster or slower change in functional connectivity with age.

Conclusions

Air pollution exposure early in life was associated with persistent alterations in connectivity between the amygdala and cortical networks involved in attention, somatomotor, and auditory function. Concurrent exposure was associated with persistent connectivity alterations between networks related to higher cognitive functions (i.e. the salience and medial-parietal networks).

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暴露于住宅空气污染和整个青春期大脑网络功能连接的发展

很少有研究将空气污染与儿童静息状态大脑网络的功能连通性差异联系起来，但空气污染暴露如何影响大脑网络的发育仍然知之甚少。因此，我们研究了从出生到3 岁以及首次影像学评估前一年的空气污染暴露与整个青春期功能连接发展的关系。方法：我们使用了来自荷兰R世代研究的3626名儿童的数据。我们利用土地利用回归模型估算了居民对PM10、PM2.5、PM2.5吸收、NOX和NO2的暴露。在两次评估（8.6-12.0和12.6-17.1 年）中，计算了13个皮质网络、杏仁核、海马体和尾状核的网络间和网络内功能连通性，共对3,626个人进行了4,628次扫描（评估1为2,511次，评估2为2,117次）。我们研究了空气污染与功能连通性之间的关系，采用线性混合模型，调整了生活方式和社会经济变量，并进行了多重检验。结果：从出生到3 岁，暴露在PM2.5中的较高水平与整个青春期杏仁核与腹侧注意、体运动手和听觉网络之间的功能连通性持续降低有关(例如- 0.027功能连通性[95 % CI - 0.040；- 0.013]杏仁核-腹侧注意网络每5 μg/m3高PM2.5)。首次影像学评估前一年暴露于PM10较高，与整个青春期显著性和中顶叶网络之间的功能连通性持续降低有关。空气污染与功能连接随年龄变化的快慢无关。结论：早期接触空气污染与杏仁核和皮层网络之间的连通性持续改变有关，这些网络涉及注意力、躯体运动和听觉功能。同时暴露与与高级认知功能相关的网络（即突出网络和中顶叶网络）之间的持续连通性改变有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.