Toxicity of 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) on oligodendrocytes during embryonic zebrafish development

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2025-01-03 DOI:10.1016/j.etap.2025.104627

Ryann Henry, Reagan Vander Heide, Nicole M. Roy

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引用次数: 0

Abstract

Polybrominated diphenyl ethers (PBDEs) are flame retardants heavily utilized across plastic, textile and electronic industries. Although these PBDEs are effective in protecting property and human life from fire, their high production volumes have led PBDEs to become pervasive environmental contaminants and pose an ecological and health risk as high levels have been noted in environmental media including water and sediment, wildlife and human tissue. Here we investigate the developmental neurotoxicity of 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47), one of the more dominant PBDE congeners found in human tissue, on oligodendrocytes in the hindbrain and spinal cord. We utilized the zebrafish vertebrate model system and investigated low (5 µM) and high concentrations (20 µM) of BDE-47. We find that by 6 days post-fertilization, BDE-47 negatively affects oligodendrocyte development in the hindbrain and spinal cord in a concentration dependent manner.

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2,2',4,4'-四溴联苯醚（BDE-47）对斑马鱼胚胎发育过程中少突胶质细胞的毒性。

多溴联苯醚（PBDEs）是一种广泛应用于塑料、纺织和电子工业的阻燃剂。虽然这些多溴二苯醚在保护财产和人类生命免受火灾侵害方面是有效的，但它们的高产量已导致多溴二苯醚成为普遍存在的环境污染物，并造成生态和健康风险，因为在水和沉积物、野生动物和人体组织等环境介质中发现了高水平的多溴二苯醚。在这里，我们研究了2,2',4,4'-四溴联苯醚（BDE-47）对后脑和脊髓少突胶质细胞的发育神经毒性，BDE-47是在人体组织中发现的更占优势的多溴联苯醚同系物之一。我们利用斑马鱼脊椎动物模型系统，研究了低浓度（5µM）和高浓度（20µM）的BDE-47。我们发现，在受精后6天，BDE-47以浓度依赖的方式负向影响后脑和脊髓的少突胶质细胞发育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.