National and Regional Trends in Congenital Cytomegalovirus Infection From 1998 to 2019.

IF 2.6 3区医学 Q1 OTORHINOLARYNGOLOGY

Otolaryngology- Head and Neck Surgery Pub Date : 2025-01-05 DOI:10.1002/ohn.1107

Raymond J So, Kimberley S Noij, Jiangxia Wang, Jonathan Walsh, Christine G Gourin, Carolyn M Jenks

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引用次数: 0

Abstract

Objective: To analyze temporal changes and to assess the possible effect of newborn hearing screening (NBHS) programs on changes in congenital cytomegalovirus (cCMV) diagnostic rates in the United States.

Study design: Cross-sectional study.

Setting: National Inpatient Sample (NIS) database.

Methods: Neonates with cCMV infection were identified using discharge data from the NIS database from 1998 to 2019. Neonates with cCMV infection were identified via International Classification of Diseases codes and categorized as asymptomatic versus symptomatic and with or without hearing loss. Linear regression and interrupted time series analyses were conducted to analyze changes in diagnostic rates over time. Interrupted analyses were based on the timing of NBHS implementation in geographic regions.

Results: Per 1,000,000 live births, the estimated total number of cCMV diagnoses increased from 109 in 1998 to 250 in 2019 (the estimated annual increase per 1,000,000 live births is 6.89 ([95% confidence interval, 5.43-8.35], P < .001). Diagnosis of cCMV with hearing loss showed a significant annual increase during this time (0.87 [0.51-1.22], P < .001), and within this group, diagnosis of both asymptomatic (0.18 [0.03-0.32], P = .02) and symptomatic (0.68 [0.37-0.99], P < .001) cases increased significantly. Compared to pre-NBHS, the rate of increase in cCMV diagnosis was significantly higher post-NBHS implementation in the Northeast (P < .001) and South (P = .008).

Conclusion: Implementation of state NBHS programs correlated with increasing diagnosis rates of cCMV, though cCMV education and awareness may be contributing. cCMV continues to be underdiagnosed in a large national database.

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1998 - 2019年先天性巨细胞病毒感染的国家和地区趋势。

目的：分析美国新生儿听力筛查（NBHS）计划对先天性巨细胞病毒（cCMV）诊断率变化的影响。研究设计：横断面研究。环境：国家住院病人样本（NIS）数据库。方法：利用1998 - 2019年NIS数据库的出院数据对cCMV感染新生儿进行鉴定。通过国际疾病分类代码对cCMV感染的新生儿进行鉴定，并将其分为无症状和有症状以及伴有或不伴有听力损失。采用线性回归和中断时间序列分析来分析诊断率随时间的变化。中断分析是基于地理区域实施NBHS的时间。结果：cCMV诊断总数从1998年的每100万活产109例增加到2019年的250例(估计每100万活产每年增加6.89例（95%置信区间，5.43-8.35）。结论：国家NBHS计划的实施与cCMV诊断率的提高相关，尽管cCMV教育和意识可能有所贡献。在一个大型国家数据库中，cCMV仍未得到充分诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

6.70

自引率

2.90%

发文量

250

审稿时长

2-4 weeks

期刊介绍： Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.